Glutathione S-transferase 3, mitochondrial (MGST3)

About Glutathione S-transferase 3, mitochondrial

Glutathione S-transferase 3, mitochondrial (MGST3) is a protein from Homo sapiens identified by UniProt accession O14880, 152 residues long. MolForge cross-references it against 0 known binders and 31 disease associations.

Target properties

Protein name	Glutathione S-transferase 3, mitochondrial
UniProt accession	O14880
Gene	MGST3
Organism	Homo sapiens
Length	152 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (31)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.50
leukocyte count · score 0.37
neutrophil count · score 0.30
body height · score 0.29
granulocyte count · score 0.21
age-related hearing impairment · score 0.03
esophageal squamous cell carcinoma · score 0.03
neoplasm · score 0.02
type 2 diabetes mellitus · score 0.02
chronic obstructive pulmonary disease · score 0.01

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O14880-F1	alphafold	PREDICTED	92.20	—

Amino-acid sequence (152 residues)

MAVLSKEYGF VLLTGAASFI MVAHLAINVS KARKKYKVEY PIMYSTDPEN GHIFNCIQRA HQNTLEVYPP FLFFLAVGGV YHPRIASGLG LAWIVGRVLY AYGYYTGEPS KRSRGALGSI ALLGLVGTTV CSAFQHLGWV KSGLGSGPKC CH

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards