About Gem-associated protein 2
Gem-associated protein 2 (GEMIN2) is a protein
from Homo sapiens identified by UniProt accession
O14893, 280 residues long.
MolForge cross-references it against 0 known binders and
26 disease associations.
Target properties
| Protein name | Gem-associated protein 2 |
|---|
| UniProt accession | O14893 |
|---|
| Gene | GEMIN2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 280 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (26)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.52
- vitamin D measurement · score 0.26
- self reported educational attainment · score 0.16
- hypertension · score 0.15
- seasonality measurement · score 0.12
- gut microbiome measurement · score 0.07
- platelet component distribution width · score 0.06
- body mass index · score 0.06
- HIV-1 infection · score 0.04
- lymphocyte count · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O14893-F1 | alphafold | PREDICTED | 80.80 | — |
Amino-acid sequence (280 residues)
MRRAELAGLK TMAWVPAESA VEELMPRLLP VEPCDLTEGF DPSVPPRTPQ EYLRRVQIEA AQCPDVVVAQ IDPKKLKRKQ SVNISLSGCQ PAPEGYSPTL QWQQQQVAQF STVRQNVNKH RSHWKSQQLD SNVTMPKSED EEGWKKFCLG EKLCADGAVG PATNESPGID YVQIGFPPLL SIVSRMNQAT VTSVLEYLSN WFGERDFTPE LGRWLYALLA CLEKPLLPEA HSLIRQLARR CSEVRLLVDS KDDERVPALN LLICLVSRYF DQRDLADEPS
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