Interferon regulatory factor 6 (IRF6)

About Interferon regulatory factor 6

Interferon regulatory factor 6 (IRF6) is a protein from Homo sapiens identified by UniProt accession O14896, 467 residues long. MolForge cross-references it against 0 known binders and 404 disease associations.

Target properties

Protein name	Interferon regulatory factor 6
UniProt accession	O14896
Gene	IRF6
Organism	Homo sapiens
Length	467 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (404)

Diseases linked to this target (Open Targets).

van der Woude syndrome 1 · score 0.79
autosomal dominant popliteal pterygium syndrome · score 0.76
van der Woude syndrome · score 0.76
popliteal pterygium syndrome · score 0.73
Cleft palate · score 0.59
cleft palate · score 0.48
cleft lip · score 0.47
tooth agenesis · score 0.41
genetic disorder · score 0.41
Orofacial cleft · score 0.29

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O14896-F1	alphafold	PREDICTED	73.50	—

Amino-acid sequence (467 residues)

MALHPRRVRL KPWLVAQVDS GLYPGLIWLH RDSKRFQIPW KHATRHSPQQ EEENTIFKAW AVETGKYQEG VDDPDPAKWK AQLRCALNKS REFNLMYDGT KEVPMNPVKI YQVCDIPQPQ GSIINPGSTG SAPWDEKDND VDEEDEEDEL DQSQHHVPIQ DTFPFLNING SPMAPASVGN CSVGNCSPEA VWPKTEPLEM EVPQAPIQPF YSSPELWISS LPMTDLDIKF QYRGKEYGQT MTVSNPQGCR LFYGDLGPMP DQEELFGPVS LEQVKFPGPE HITNEKQKLF TSKLLDVMDR GLILEVSGHA IYAIRLCQCK VYWSGPCAPS LVAPNLIERQ KKVKLFCLET FLSDLIAHQK GQIEKQPPFE IYLCFGEEWP DGKPLERKLI LVQVIPVVAR MIYEMFSGDF TRSFDSGSVR LQISTPDIKD NIVAQLKQLY RILQTQESWQ PMQPTPSMQL PPALPPQ

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards