PDZ domain-containing protein GIPC1 (GIPC1)

About PDZ domain-containing protein GIPC1

PDZ domain-containing protein GIPC1 (GIPC1) is a protein from Homo sapiens identified by UniProt accession O14908, 333 residues long. MolForge cross-references it against 0 known binders and 129 disease associations.

Target properties

Protein name	PDZ domain-containing protein GIPC1
UniProt accession	O14908
Gene	GIPC1
Organism	Homo sapiens
Length	333 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (129)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.46
oculopharyngodistal myopathy 2 · score 0.45
oculopharyngodistal myopathy · score 0.37
urate measurement · score 0.22
bone density · score 0.22
familial idiopathic steroid-resistant nephrotic syndrome · score 0.07
gonorrhea · score 0.07
nephrotic syndrome · score 0.07
uridine-cytidineuria · score 0.07
isolated sedoheptulokinase deficiency · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O14908-F1	alphafold	PREDICTED	80.53	—

Amino-acid sequence (333 residues)

MPLGLGRRKK APPLVENEEA EPGRGGLGVG EPGPLGGGGS GGPQMGLPPP PPALRPRLVF HTQLAHGSPT GRIEGFTNVK ELYGKIAEAF RLPTAEVMFC TLNTHKVDMD KLLGGQIGLE DFIFAHVKGQ RKEVEVFKSE DALGLTITDN GAGYAFIKRI KEGSVIDHIH LISVGDMIEA INGQSLLGCR HYEVARLLKE LPRGRTFTLK LTEPRKAFDM ISQRSAGGRP GSGPQLGTGR GTLRLRSRGP ATVEDLPSAF EEKAIEKVDD LLESYMGIRD TELAATMVEL GKDKRNPDEL AEALDERLGD FAFPDEFVFD VWGAIGDAKV GRY

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards