Mitochondrial import inner membrane translocase…

About Mitochondrial import inner membrane translocase subunit Tim23

Mitochondrial import inner membrane translocase subunit Tim23 (TIMM23) is a protein from Homo sapiens identified by UniProt accession O14925, 209 residues long. MolForge cross-references it against 0 known binders and 56 disease associations.

Target properties

Protein name	Mitochondrial import inner membrane translocase subunit Tim23
UniProt accession	O14925
Gene	TIMM23
Organism	Homo sapiens
Length	209 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (56)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.45
mean corpuscular volume · score 0.21
red blood cell density measurement · score 0.15
Red cell distribution width · score 0.13
mean corpuscular hemoglobin · score 0.06
Alopecia universalis · score 0.05
erythrocyte count · score 0.04
hypotrichosis simplex · score 0.04
trichodysplasia-xeroderma syndrome · score 0.03
alopecia universalis congenita · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O14925-F1	alphafold	PREDICTED	59.21	—

Amino-acid sequence (209 residues)

MEGGGGSGNK TTGGLAGFFG AGGAGYSHAD LAGVPLTGMN PLSPYLNVDP RYLVQDTDEF ILPTGANKTR GRFELAFFTI GGCCMTGAAF GAMNGLRLGL KETQNMAWSK PRNVQILNMV TRQGALWANT LGSLALLYSA FGVIIEKTRG AEDDLNTVAA GTMTGMLYKC TGGLRGIARG GLTGLTLTSL YALYNNWEHM KGSLLQQSL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Mitochondrial import inner membrane translocase subunit Tim23 (TIMM23)