Ubiquitin/ISG15-conjugating enzyme E2 L6 (UBE2L6)

About Ubiquitin/ISG15-conjugating enzyme E2 L6

Ubiquitin/ISG15-conjugating enzyme E2 L6 (UBE2L6) is a protein from Homo sapiens identified by UniProt accession O14933, 153 residues long. MolForge cross-references it against 0 known binders and 89 disease associations.

Target properties

Protein name	Ubiquitin/ISG15-conjugating enzyme E2 L6
UniProt accession	O14933
Gene	UBE2L6
Organism	Homo sapiens
Length	153 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (89)

Diseases linked to this target (Open Targets).

urate measurement · score 0.26
Dental malocclusion · score 0.22
plasma protease C1 inhibitor measurement · score 0.19
monocyte count · score 0.18
breast adenocarcinoma · score 0.18
inflammatory bowel disease · score 0.14
melanoma · score 0.08
neoplasm · score 0.05
mathematical ability · score 0.05
BMI-adjusted waist circumference · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O14933-F1	alphafold	PREDICTED	95.15	—

Amino-acid sequence (153 residues)

MMASMRVVKE LEDLQKKPPP YLRNLSSDDA NVLVWHALLL PDQPPYHLKA FNLRISFPPE YPFKPPMIKF TTKIYHPNVD ENGQICLPII SSENWKPCTK TCQVLEALNV LVNRPNIREP LRMDLADLLT QNPELFRKNA EEFTLRFGVD RPS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards