Proepiregulin (EREG)

About Proepiregulin

Proepiregulin (EREG) is a protein from Homo sapiens identified by UniProt accession O14944, 169 residues long. MolForge cross-references it against 0 known binders and 288 disease associations.

Target properties

Protein name	Proepiregulin
UniProt accession	O14944
Gene	EREG
Organism	Homo sapiens
Length	169 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (288)

Diseases linked to this target (Open Targets).

cancer · score 0.60
lung adenocarcinoma · score 0.30
multiple myeloma · score 0.29
endometrial cancer · score 0.29
cutaneous melanoma · score 0.27
coronary artery calcification · score 0.25
gastric adenocarcinoma · score 0.25
colorectal adenocarcinoma · score 0.19
mammographic density measurement · score 0.12
dense area measurement · score 0.12

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O14944-F1	alphafold	PREDICTED	68.66	—

Amino-acid sequence (169 residues)

MTAGRRMEML CAGRVPALLL CLGFHLLQAV LSTTVIPSCI PGESSDNCTA LVQTEDNPRV AQVSITKCSS DMNGYCLHGQ CIYLVDMSQN YCRCEVGYTG VRCEHFFLTV HQPLSKEYVA LTVILIILFL ITVVGSTYYF CRWYRNRKSK EPKKEYERVT SGDPELPQV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards