Transcription factor EC (TFEC)

About Transcription factor EC

Transcription factor EC (TFEC) is a protein from Homo sapiens identified by UniProt accession O14948, 347 residues long. MolForge cross-references it against 0 known binders and 80 disease associations.

Target properties

Protein name	Transcription factor EC
UniProt accession	O14948
Gene	TFEC
Organism	Homo sapiens
Length	347 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (80)

Diseases linked to this target (Open Targets).

platelet count · score 0.45
intraocular pressure measurement · score 0.45
chronotype measurement · score 0.43
glaucoma · score 0.35
PHF-tau measurement · score 0.32
platelet crit · score 0.31
risk-taking behaviour · score 0.28
platelet component distribution width · score 0.27
risky sexual behaviour measurement · score 0.19
body mass index · score 0.15

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O14948-F1	alphafold	PREDICTED	62.23	—

Amino-acid sequence (347 residues)

MTLDHQIINP TLKWSQPAVP SGGPLVQHAH TTLDSDAGLT ENPLTKLLAI GKEDDNAQWH MEDVIEDIIG MESSFKEEGA DSPLLMQRTL SGSILDVYSG EQGISPINMG LTSASCPSSL PMKREITETD TRALAKERQK KDNHNLIERR RRYNINYRIK ELGTLIPKSN DPDMRWNKGT ILKASVEYIK WLQKEQQRAR ELEHRQKKLE QANRRLLLRI QELEIQARTH GLPTLASLGT VDLGAHVTKQ QSHPEQNSVD YCQQLTVSQG PSPELCDQAI AFSDPLSYFT DLSFSAALKE EQRLDGMLLD DTISPFGTDP LLSATSPAVS KESSRRSSFS SDDGDEL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards