Cytochrome b-c1 complex subunit 8 (UQCRQ)

About Cytochrome b-c1 complex subunit 8

Cytochrome b-c1 complex subunit 8 (UQCRQ) is a protein from Homo sapiens identified by UniProt accession O14949, 82 residues long. MolForge cross-references it against 0 known binders and 58 disease associations.

Target properties

Protein name	Cytochrome b-c1 complex subunit 8
UniProt accession	O14949
Gene	UQCRQ
Organism	Homo sapiens
Length	82 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (58)

Diseases linked to this target (Open Targets).

Isolated CoQ-cytochrome C reductase deficiency · score 0.56
neurodegenerative disease · score 0.56
lysosomal storage disease · score 0.29
Alzheimer disease · score 0.27
Parkinson disease · score 0.27
multiple sclerosis · score 0.27
mitochondrial complex III deficiency nuclear type 1 · score 0.12
neuroinflammatory disorder · score 0.12
thrombocytopenia 4 · score 0.07
macrothrombocytopenia, isolated, 2, autosomal dominant · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O14949-F1	alphafold	PREDICTED	94.48	—

Amino-acid sequence (82 residues)

MGREFGNLTR MRHVISYSLS PFEQRAYPHV FTKGIPNVLR RIRESFFRVV PQFVVFYLIY TWGTEEFERS KRKNPAAYEN DK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards