About Myosin regulatory light chain 12B
Myosin regulatory light chain 12B (MYL12B) is a protein
from Homo sapiens identified by UniProt accession
O14950, 172 residues long.
MolForge cross-references it against 0 known binders and
97 disease associations.
Target properties
| Protein name | Myosin regulatory light chain 12B |
|---|
| UniProt accession | O14950 |
|---|
| Gene | MYL12B |
|---|
| Organism | Homo sapiens |
|---|
| Length | 172 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (97)
Diseases linked to this target (Open Targets).
- breast adenocarcinoma · score 0.21
- head and neck squamous cell carcinoma · score 0.19
- lung adenocarcinoma · score 0.18
- nephrolithiasis · score 0.18
- ureterolithiasis · score 0.18
- cutaneous melanoma · score 0.13
- respiratory system disease · score 0.12
- dehydrated hereditary stomatocytosis · score 0.05
- Rh deficiency syndrome · score 0.05
- hemoglobin E-beta-thalassemia syndrome · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O14950-F1 | alphafold | PREDICTED | 83.52 | — |
Amino-acid sequence (172 residues)
MSSKKAKTKT TKKRPQRATS NVFAMFDQSQ IQEFKEAFNM IDQNRDGFID KEDLHDMLAS LGKNPTDAYL DAMMNEAPGP INFTMFLTMF GEKLNGTDPE DVIRNAFACF DEEATGTIQE DYLRELLTTM GDRFTDEEVD ELYREAPIDK KGNFNYIEFT RILKHGAKDK DD
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