Calsequestrin-2 (CASQ2)

About Calsequestrin-2

Calsequestrin-2 (CASQ2) is a protein from Homo sapiens identified by UniProt accession O14958, 399 residues long. MolForge cross-references it against 0 known binders and 246 disease associations.

Target properties

Protein name	Calsequestrin-2
UniProt accession	O14958
Gene	CASQ2
Organism	Homo sapiens
Length	399 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (246)

Diseases linked to this target (Open Targets).

catecholaminergic polymorphic ventricular tachycardia · score 0.72
catecholaminergic polymorphic ventricular tachycardia 1 · score 0.59
Abnormality of the cardiovascular system · score 0.54
electrocardiography · score 0.49
atrial fibrillation · score 0.44
QRS duration · score 0.42
pulse pressure measurement · score 0.39
neurodegenerative disease · score 0.30
heart function measurement · score 0.30
Prolonged QT interval · score 0.30

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O14958-F1	alphafold	PREDICTED	90.51	—

Amino-acid sequence (399 residues)

MKRTHLFIVG IYFLSSCRAE EGLNFPTYDG KDRVVSLSEK NFKQVLKKYD LLCLYYHEPV SSDKVTQKQF QLKEIVLELV AQVLEHKAIG FVMVDAKKEA KLAKKLGFDE EGSLYILKGD RTIEFDGEFA ADVLVEFLLD LIEDPVEIIS SKLEVQAFER IEDYIKLIGF FKSEDSEYYK AFEEAAEHFQ PYIKFFATFD KGVAKKLSLK MNEVDFYEPF MDEPIAIPNK PYTEEELVEF VKEHQRPTLR RLRPEEMFET WEDDLNGIHI VAFAEKSDPD GYEFLEILKQ VARDNTDNPD LSILWIDPDD FPLLVAYWEK TFKIDLFRPQ IGVVNVTDAD SVWMEIPDDD DLPTAEELED WIEDVLSGKI NTEDDDEDDD DDDNSDEEDN DDSDDDDDE

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards