Aurora kinase A (AURKA)

About Aurora kinase A

Aurora kinase A (AURKA) is a protein from Homo sapiens identified by UniProt accession O14965, 403 residues long. MolForge cross-references it against 0 known binders and 430 disease associations.

Target properties

Protein name	Aurora kinase A
UniProt accession	O14965
Gene	AURKA
Organism	Homo sapiens
Length	403 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (16)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (430)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.52
Alzheimer disease · score 0.51
Parkinson disease · score 0.50
lysosomal storage disease · score 0.50
multiple sclerosis · score 0.50
mean corpuscular volume · score 0.37
mean corpuscular hemoglobin · score 0.31
glioblastoma multiforme · score 0.31
mean corpuscular hemoglobin concentration · score 0.31
multiple myeloma · score 0.29

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O14965-F1	alphafold	PREDICTED	75.03	—

Amino-acid sequence (403 residues)

MDRSKENCIS GPVKATAPVG GPKRVLVTQQ FPCQNPLPVN SGQAQRVLCP SNSSQRIPLQ AQKLVSSHKP VQNQKQKQLQ ATSVPHPVSR PLNNTQKSKQ PLPSAPENNP EEELASKQKN EESKKRQWAL EDFEIGRPLG KGKFGNVYLA REKQSKFILA LKVLFKAQLE KAGVEHQLRR EVEIQSHLRH PNILRLYGYF HDATRVYLIL EYAPLGTVYR ELQKLSKFDE QRTATYITEL ANALSYCHSK RVIHRDIKPE NLLLGSAGEL KIADFGWSVH APSSRRTTLC GTLDYLPPEM IEGRMHDEKV DLWSLGVLCY EFLVGKPPFE ANTYQETYKR ISRVEFTFPD FVTEGARDLI SRLLKHNPSQ RPMLREVLEH PWITANSSKP SNCQNKESAS KQS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards