About Calmegin
Calmegin (CLGN) is a protein
from Homo sapiens identified by UniProt accession
O14967, 610 residues long.
MolForge cross-references it against 0 known binders and
129 disease associations.
Target properties
| Protein name | Calmegin |
|---|
| UniProt accession | O14967 |
|---|
| Gene | CLGN |
|---|
| Organism | Homo sapiens |
|---|
| Length | 610 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (129)
Diseases linked to this target (Open Targets).
- sodium measurement · score 0.36
- Short stature · score 0.35
- mean arterial pressure · score 0.27
- systolic blood pressure · score 0.27
- diastolic blood pressure · score 0.27
- hepatocellular carcinoma · score 0.08
- azoospermia · score 0.08
- Rare genetic female infertility · score 0.08
- Female infertility due to fertilization defect · score 0.07
- male infertility with teratozoospermia due to single gene mutation · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O14967-F1 | alphafold | PREDICTED | 76.28 | — |
Amino-acid sequence (610 residues)
MHFQAFWLCL GLLFISINAE FMDDDVETED FEENSEEIDV NESELSSEIK YKTPQPIGEV YFAETFDSGR LAGWVLSKAK KDDMDEEISI YDGRWEIEEL KENQVPGDRG LVLKSRAKHH AISAVLAKPF IFADKPLIVQ YEVNFQDGID CGGAYIKLLA DTDDLILENF YDKTSYIIMF GPDKCGEDYK LHFIFRHKHP KTGVFEEKHA KPPDVDLKKF FTDRKTHLYT LVMNPDDTFE VLVDQTVVNK GSLLEDVVPP IKPPKEIEDP NDKKPEEWDE RAKIPDPSAV KPEDWDESEP AQIEDSSVVK PAGWLDDEPK FIPDPNAEKP DDWNEDTDGE WEAPQILNPA CRIGCGEWKP PMIDNPKYKG VWRPPLVDNP NYQGIWSPRK IPNPDYFEDD HPFLLTSFSA LGLELWSMTS DIYFDNFIIC SEKEVADHWA ADGWRWKIMI ANANKPGVLK QLMAAAEGHP WLWLIYLVTA GVPIALITSF CWPRKVKKKH KDTEYKKTDI CIPQTKGVLE QEEKEEKAAL EKPMDLEEEK KQNDGEMLEK EEESEPEEKS EEEIEIIEGQ EESNQSNKSG SEDEMKEADE STGSGDGPIK SVRKRRVRKD
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