About Heterogeneous nuclear ribonucleoprotein D-like
Heterogeneous nuclear ribonucleoprotein D-like (HNRNPDL) is a protein
from Homo sapiens identified by UniProt accession
O14979, 420 residues long.
MolForge cross-references it against 0 known binders and
65 disease associations.
Target properties
| Protein name | Heterogeneous nuclear ribonucleoprotein D-like |
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| UniProt accession | O14979 |
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| Gene | HNRNPDL |
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| Organism | Homo sapiens |
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| Length | 420 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (65)
Diseases linked to this target (Open Targets).
- autosomal dominant limb-girdle muscular dystrophy type 1G · score 0.63
- limb-girdle muscular dystrophy · score 0.37
- muscular dystrophy, limb-girdle, autosomal dominant · score 0.18
- Rheumatoid arthritis · score 0.07
- adolescent idiopathic scoliosis · score 0.07
- eosinophil peroxidase deficiency · score 0.06
- linear and whorled nevoid hypermelanosis · score 0.06
- chronic myeloproliferative disorder · score 0.05
- chronic myelogenous leukemia · score 0.04
- mathematical ability · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O14979-F1 | alphafold | PREDICTED | 62.78 | — |
Amino-acid sequence (420 residues)
MEVPPRLSHV PPPLFPSAPA TLASRSLSHW RPRPPRQLAP LLPSLAPSSA RQGARRAQRH VTAQQPSRLA GGAAIKGGRR RRPDLFRRHF KSSSIQRSAA AAAATRTARQ HPPADSSVTM EDMNEYSNIE EFAEGSKINA SKNQQDDGKM FIGGLSWDTS KKDLTEYLSR FGEVVDCTIK TDPVTGRSRG FGFVLFKDAA SVDKVLELKE HKLDGKLIDP KRAKALKGKE PPKKVFVGGL SPDTSEEQIK EYFGAFGEIE NIELPMDTKT NERRGFCFIT YTDEEPVKKL LESRYHQIGS GKCEIKVAQP KEVYRQQQQQ QKGGRGAAAG GRGGTRGRGR GQGQNWNQGF NNYYDQGYGN YNSAYGGDQN YSGYGGYDYT GYNYGNYGYG QGYADYSGQQ STYGKASRGG GNHQNNYQPY
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