About Phosphatidylinositol 4-phosphate 5-kinase type-1 beta
Phosphatidylinositol 4-phosphate 5-kinase type-1 beta (PIP5K1B) is a protein
from Homo sapiens identified by UniProt accession
O14986, 540 residues long.
MolForge cross-references it against 0 known binders and
73 disease associations.
Target properties
| Protein name | Phosphatidylinositol 4-phosphate 5-kinase type-1 beta |
|---|
| UniProt accession | O14986 |
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| Gene | PIP5K1B |
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| Organism | Homo sapiens |
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| Length | 540 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (73)
Diseases linked to this target (Open Targets).
- calcium measurement · score 0.47
- glomerular filtration rate · score 0.42
- creatinine measurement · score 0.38
- neuroinflammatory disorder · score 0.31
- blood phosphate measurement · score 0.30
- urate measurement · score 0.29
- glioblastoma multiforme · score 0.29
- cystatin C measurement · score 0.29
- chronic kidney disease · score 0.29
- breast adenocarcinoma · score 0.29
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O14986-F1 | alphafold | PREDICTED | 69.03 | — |
Amino-acid sequence (540 residues)
MSSAAENGEA APGKQNEEKT YKKTASSAIK GAIQLGIGYT VGNLTSKPER DVLMQDFYVV ESVFLPSEGS NLTPAHHYPD FRFKTYAPLA FRYFRELFGI KPDDYLYSIC SEPLIELSNP GASGSLFFVT SDDEFIIKTV QHKEAEFLQK LLPGYYMNLN QNPRTLLPKF YGLYCMQSGG INIRIVVMNN VLPRSMRMHF TYDLKGSTYK RRASRKEREK SNPTFKDLDF LQDMHEGLYF DTETYNALMK TLQRDCRVLE SFKIMDYSLL LGIHFLDHSL KEKEEETPQN VPDAKRTGMQ KVLYSTAMES IQGPGKSGDG IITENPDTMG GIPAKSHRGE KLLLFMGIID ILQSYRLMKK LEHSWKALVY DGDTVSVHRP SFYADRFLKF MNSRVFKKIQ ALKASPSKKR CNSIAALKAT SQEIVSSISQ EWKDEKRDLL TEGQSFSSLD EEALGSRHRP DLVPSTPSLF EAASLATTIS SSSLYVNEHY PHDRPTLYSN SKGLPSSSTF TLEEGTIYLT AEPNTLEVQD DNASVLDVYL
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