About Rho guanine nucleotide exchange factor 10
Rho guanine nucleotide exchange factor 10 (ARHGEF10) is a protein
from Homo sapiens identified by UniProt accession
O15013, 1369 residues long.
MolForge cross-references it against 0 known binders and
203 disease associations.
Target properties
| Protein name | Rho guanine nucleotide exchange factor 10 |
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| UniProt accession | O15013 |
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| Gene | ARHGEF10 |
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| Organism | Homo sapiens |
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| Length | 1369 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (203)
Diseases linked to this target (Open Targets).
- autosomal dominant slowed nerve conduction velocity · score 0.54
- Charcot-Marie-Tooth disease · score 0.31
- response to polyunsaturated fatty acid supplementation · score 0.30
- delta-6 desaturase measurement · score 0.30
- axonal neuropathy · score 0.27
- peripheral neuropathy · score 0.26
- non-small cell lung carcinoma · score 0.21
- pancreatic ductal adenocarcinoma · score 0.19
- gastric carcinoma · score 0.19
- hepatocellular carcinoma · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O15013-F1 | alphafold | PREDICTED | 64.96 | — |
Amino-acid sequence (1369 residues)
MRPPGFLSRA PSLNRAERGI WSCSMDQREP LPPAPAENEM KYDTNNNEEE EGEQFDFDSG DEIPEADRQA PSAPETGGAG ASEAPAPTGG EDGAGAETTP VAEPTKLVLP MKVNPYSVID ITPFQEDQPP TPVPSAEEEN VGLHVPCGYL VPVPCGYAVP SNLPLLLPAY SSPVIICATS LDEEAETPEV TEDRQPNSLS SEEPPTSEDQ VGREDSALAR WAADPANTAW MENPEEAIYD DVPRENSDSE PDEMIYDDVE NGDEGGNSSL EYGWSSSEFE SYEEQSDSEC KNGIPRSFLR SNHKKQLSHD LTRLKEHYEK KMRDLMASTV GVVEIQQLRQ KHELKMQKLV KAAKDGTKDG LERTRAAVKR GRSFIRTKSL IAQDHRSSLE EEQNLFIDVD CKHPEAILTP MPEGLSQQQV VRRYILGSVV DSEKNYVDAL KRILEQYEKP LSEMEPKVLS ERKLKTVFYR VKEILQCHSL FQIALASRVS EWDSVEMIGD VFVASFSKSM VLDAYSEYVN NFSTAVAVLK KTCATKPAFL EFLKQEQEAS PDRTTLYSLM MKPIQRFPQF ILLLQDMLKN TSKGHPDRLP LQMALTELET LAEKLNERKR DADQRCEVKQ IAKAINERYL NKLLSSGSRY LIRSDDMIET VYNDRGEIVK TKERRVFMLN DVLMCATVSS RPSHDSRVMS SQRYLLKWSV PLGHVDAIEY GSSAGTGEHS RHLAVHPPES LAVVANAKPN KVYMGPGQLY QDLQNLLHDL NVIGQITQLI GNLKGNYQNL NQSVAHDWTS GLQRLILKKE DEIRAADCCR IQLQLPGKQD KSGRPTFFTA VFNTFTPAIK ESWVNSLQMA KLALEEENHM GWFCVEDDGN HIKKEKHPLL VGHMPVMVAK QQEFKIECAA YNPEPYLNNE SQPDSFSTAH GFLWIGSCTH QMGQIAIVSF QNSTPKVIEC FNVESRILCM LYVPVEEKRR EPGAPPDPET PAVRASDVPT ICVGTEEGSI SIYKSSQGSK KVRLQHFFTP EKSTVMSLAC TSQSLYAGLV NGAVASYARA PDGSWDSEPQ KVIKLGVLPV RSLLMMEDTL WAASGGQVFI ISVETHAVEG QLEAHQEEGM VISHMAVSGV GIWIAFTSGS TLRLFHTETL KHLQDINIAT PVHNMLPGHQ RLSVTSLLVC HGLLMVGTSL GVLVALPVPR LQGIPKVTGR GMVSYHAHNS PVKFIVLATA LHEKDKDKSR DSLAPGPEPQ DEDQKDALPS GGAGSSLSQG DPDAAIWLGD SLGSMTQKSD LSSSSGSLSL SHGSSSLEHR SEDSTIYDLL KDPVSLRSKA RRAKKAKASS ALVVCGGQGH RRVHRKARQP HQEELAPTVM VWQIPLLNI
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