About Zinc finger protein 646
Zinc finger protein 646 (ZNF646) is a protein
from Homo sapiens identified by UniProt accession
O15015, 1832 residues long.
MolForge cross-references it against 0 known binders and
71 disease associations.
Target properties
| Protein name | Zinc finger protein 646 |
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| UniProt accession | O15015 |
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| Gene | ZNF646 |
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| Organism | Homo sapiens |
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| Length | 1832 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (71)
Diseases linked to this target (Open Targets).
- sex hormone-binding globulin measurement · score 0.31
- body fat percentage · score 0.26
- response to anticoagulant · score 0.23
- hip circumference · score 0.23
- waist circumference · score 0.23
- high density lipoprotein cholesterol measurement · score 0.22
- body fat distribution · score 0.21
- serum alanine aminotransferase measurement · score 0.19
- aspartate aminotransferase measurement · score 0.19
- low density lipoprotein triglyceride measurement · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O15015-F1 | alphafold | PREDICTED | 49.83 | — |
Amino-acid sequence (1832 residues)
MEDTPPSLSC SDCQRHFPSL PELSRHRELL HPSPNQDSEE ADSIPRPYRC QQCGRGYRHP GSLVNHRRTH ETGLFPCTTC GKDFSNPMAL KSHMRTHAPE GRRRHRPPRP KEATPHLQGE TVSTDSWGQR LGSSEGWENQ TKHTEETPDC ESVPDPRAAS GTWEDLPTRQ REGLASHPGP EDGADGWGPS TNSARAPPLP IPASSLLSNL EQYLAESVVN FTGGQEPTQS PPAEEERRYK CSQCGKTYKH AGSLTNHRQS HTLGIYPCAI CFKEFSNLMA LKNHSRLHAQ YRPYHCPHCP RVFRLPRELL EHQQSHEGER QEPRWEEKGM PTTNGHTDES SQDQLPSAQM LNGSAELSTS GELEDSGLEE YRPFRCGDCG RTYRHAGSLI NHRKSHQTGV YPCSLCSKQL FNAAALKNHV RAHHRPRQGV GENGQPSVPP APLLLAETTH KEEEDPTTTL DHRPYKCSEC GRAYRHRGSL VNHRHSHRTG EYQCSLCPRK YPNLMALRNH VRVHCKAARR SADIGAEGAP SHLKVELPPD PVEAEAAPHT DQDHVCKHEE EATDITPAAD KTAAHICSIC GLLFEDAESL ERHGLTHGAG EKENSRTETT MSPPRAFACR DCGKSYRHSG SLINHRQTHQ TGDFSCGACA KHFHTMAAMK NHLRRHSRRR SRRHRKRAGG ASGGREAKLL AAESWTRELE DNEGLESPQD PSGESPHGAE GNLESDGDCL QAESEGDKCG LERDETHFQG DKESGGTGEG LERKDASLLD NLDIPGEEGG GTHFCDSLTG VDEDQKPATG QPNSSSHSAN AVTGWQAGAA HTCSDCGHSF PHATGLLSHR PCHPPGIYQC SLCPKEFDSL PALRSHFQNH RPGEATSAQP FLCCLCGMIF PGRAGYRLHR RQAHSSSGMT EGSEEEGEEE GVAEAAPARS PPLQLSEAEL LNQLQREVEA LDSAGYGHIC GCCGQTYDDL GSLERHHQSQ SSGTTADKAP SPLGVAGDAM EMVVDSVLED IVNSVSGEGG DAKSQEGAGT PLGDSLCIQG GESLLEAQPR PFRCNQCGKT YRHGGSLVNH RKIHQTGDFL CPVCSRCYPN LAAYRNHLRN HPRCKGSEPQ VGPIPEAAGS SELQVGPIPE GGSNKPQHMA EEGPGQAEVE KLQEELKVEP LEEVARVKEE VWEETTVKGE EIEPRLETAE KGCQTEASSE RPFSCEVCGR SYKHAGSLIN HRQSHQTGHF GCQACSKGFS NLMSLKNHRR IHADPRRFRC SECGKAFRLR KQLASHQRVH MERRGGGGTR KATREDRPFR CGQCGRTYRH AGSLLNHRRS HETGQYSCPT CPKTYSNRMA LKDHQRLHSE NRRRRAGRSR RTAVRCALCG RSFPGRGSLE RHLREHEETE REPANGQGGL DGTAASEANL TGSQGLETQL GGAEPVPHLE DGVPRPGERS QSPIRAASSE APEPLSWGAG KAGGWPVGGG LGNHSGGWVP QFLTRSEEPE DSVHRSPCHA GDCQLNGPTL SHMDSWDNRD NSSQLQPGSH SSCSQCGKTY CQSGSLLNHN TNKTDRHYCL LCSKEFLNPV ATKSHSHNHI DAQTFACPDC GKAFESHQEL ASHLQAHARG HSQVPAQMEE ARDPKAGTGE DQVVLPGQGK AQEAPSETPR GPGESVERAR GGQAVTSMAA EDKERPFRCT QCGRSYRHAG SLLNHQKAHT TGLYPCSLCP KLLPNLLSLK NHSRTHTDPK RHCCSICGKA FRTAARLEGH GRVHAPREGP FTCPHCPRHF RRRISFVQHQ QQHQEEWTVA GSGAPVAPVT GRGDLPLPPP PTPTTPLLDP SPQWPADLSF SL
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