About PDZ domain-containing protein 2
PDZ domain-containing protein 2 (PDZD2) is a protein
from Homo sapiens identified by UniProt accession
O15018, 2839 residues long.
MolForge cross-references it against 0 known binders and
125 disease associations.
Target properties
| Protein name | PDZ domain-containing protein 2 |
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| UniProt accession | O15018 |
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| Gene | PDZD2 |
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| Organism | Homo sapiens |
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| Length | 2839 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (125)
Diseases linked to this target (Open Targets).
- cortical thickness · score 0.35
- cortical surface area measurement · score 0.35
- cup-to-disc ratio measurement · score 0.35
- blood protein measurement · score 0.30
- brain measurement · score 0.28
- bone density · score 0.28
- urate measurement · score 0.28
- chronic obstructive pulmonary disease · score 0.27
- gut microbiome measurement · score 0.27
- optic disc size measurement · score 0.26
3D Structure (9)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
Amino-acid sequence (2839 residues)
MPITQDNAVL HLPLLYQWLQ NSLQEGGDGP EQRLCQAAIQ KLQEYIQLNF AVDESTVPPD HSPPEMEICT VYLTKELGDT ETVGLSFGNI PVFGDYGEKR RGGKKRKTHQ GPVLDVGCIW VTELRKNSPA GKSGKVRLRD EILSLNGQLM VGVDVSGASY LAEQCWNGGF IYLIMLRRFK HKAHSTYNGN SSNSSEPGET PTLELGDRTA KKGKRTRKFG VISRPPANKA PEESKGSAGC EVSSDPSTEL ENGPDPELGN GHVFQLENGP DSLKEVAGPH LERSEVDRGT EHRIPKTDAP LTTSNDKRRF SKGGKTDFQS SDCLAREEVG RIWKMELLKE SDGLGIQVSG GRGSKRSPHA IVVTQVKEGG AAHRDGRLSL GDELLVINGH LLVGLSHEEA VAILRSATGM VQLVVASKEN SAEDLLRLTS KSLPDLTSSV EDVSSWTDNE DQEADGEEDE GTSSSVQRAM PGTDEPQDVC GAEESKGNLE SPKQGSNKIK LKSRLSGGVH RLESVEEYNE LMVRNGDPRI RMLEVSRDGR KHSLPQLLDS SSASQEYHIV KKSTRSLSTT QVESPWRLIR PSVISIIGLY KEKGKGLGFS IAGGRDCIRG QMGIFVKTIF PNGSAAEDGR LKEGDEILDV NGIPIKGLTF QEAIHTFKQI RSGLFVLTVR TKLVSPSLTP CSTPTHMSRS ASPNFNTSGG ASAGGSDEGS SSSLGRKTPG PKDRIVMEVT LNKEPRVGLG IGACCLALEN SPPGIYIHSL APGSVAKMES NLSRGDQILE VNSVNVRHAA LSKVHAILSK CPPGPVRLVI GRHPNPKVSE QEMDEVIARS TYQESKEANS SPGLGTPLKS PSLAKKDSLI SESELSQYFA HDVPGPLSDF MVAGSEDEDH PGSGCSTSEE GSLPPSTSTH KEPGKPRANS LVTLGSHRAS GLFHKQVTVA RQASLPGSPQ ALRNPLLRQR KVGCYDANDA SDEEEFDREG DCISLPGALP GPIRPLSEDD PRRVSISSSK GMDVHNQEER PRKTLVSKAI SAPLLGSSVD LEESIPEGMV DAASYAANLT DSAEAPKGSP GSWWKKELSG SSSAPKLEYT VRTDTQSPTN TGSPSSPQQK SEGLGSRHRP VARVSPHCKR SEAEAKPSGS QTVNLTGRAN DPCDLDSRVQ ATSVKVTVAG FQPGGAVEKE SLGKLTTGDA CVSTSCELAS ALSHLDASHL TENLPKAASE LGQQPMTELD SSSDLISSPG KKGAAHPDPS KTSVDTGQVS RPENPSQPAS PRVTKCKARS PVRLPHEGSP SPGEKAAAPP DYSKTRSASE TSTPHNTRRV AALRGAGPGA EGMTPAGAVL PGDPLTSQEQ RQGAPGNHSK ALEMTGIHAP ESSQEPSLLE GADSVSSRAP QASLSMLPST DNTKEACGHV SGHCCPGGSR ESPVTDIDSF IKELDASAAR SPSSQTGDSG SQEGSAQGHP PAGAGGGSSC RAEPVPGGQT SSPRRAWAAG APAYPQWASQ PSVLDSINPD KHFTVNKNFL SNYSRNFSSF HEDSTSLSGL GDSTEPSLSS MYGDAEDSSS DPESLTEAPR ASARDGWSPP RSRVSLHKED PSESEEEQIE ICSTRGCPNP PSSPAHLPTQ AAICPASAKV LSLKYSTPRE SVASPREKAA CLPGSYTSGP DSSQPSSLLE MSSQEHETHA DISTSQNHRP SCAEETTEVT SASSAMENSP LSKVARHFHS PPIILSSPNM VNGLEHDLLD DETLNQYETS INAAASLSSF SVDVPKNGES VLENLHISES QDLDDLLQKP KMIARRPIMA WFKEINKHNQ GTHLRSKTEK EQPLMPARSP DSKIQMVSSS QKKGVTVPHS PPQPKTNLEN KDLSKKSPAE MLLTNGQKAK CGPKLKRLSL KGKAKVNSEA PAANAVKAGG TDHRKPLISP QTSHKTLSKA VSQRLHVADH EDPDRNTTAA PRSPQCVLES KPPLATSGPL KPSVSDTSIR TFVSPLTSPK PVPEQGMWSR FHMAVLSEPD RGCPTTPKSP KCRAEGRAPR ADSGPVSPAA SRNGMSVAGN RQSEPRLASH VAADTAQPRP TGEKGGNIMA SDRLERTNQL KIVEISAEAV SETVCGNKPA ESDRRGGCLA QGNCQEKSEI RLYRQVAESS TSHPSSLPSH ASQAEQEMSR SFSMAKLASS SSSLQTAIRK AEYSQGKSSL MSDSRGVPRN SIPGGPSGED HLYFTPRPAT RTYSMPAQFS SHFGREGHPP HSLGRSRDSQ VPVTSSVVPE AKASRGGLPS LANGQGIYSV KPLLDTSRNL PATDEGDIIS VQETSCLVTD KIKVTRRHYC YEQNWPHEST SFFSVKQRIK SFENLANADR PVAKSGASPF LSVSSKPPIG RRSSGSIVSG SLGHPGDAAA RLLRRSLSSC SENQSEAGTL LPQMAKSPSI MTLTISRQNP PETSSKGSDS ELKKSLGPLG IPTPTMTLAS PVKRNKSSVR HTQPSPVSRS KLQELRALSM PDLDKLCSED YSAGPSAVLF KTELEITPRR SPGPPAGGVS CPEKGGNRAC PGGSGPKTSA AETPSSASDT GEAAQDLPFR RSWSVNLDQL LVSAGDQQRL QSVLSSVGSK STILTLIQEA KAQSENEEDV CFIVLNRKEG SGLGFSVAGG TDVEPKSITV HRVFSQGAAS QEGTMNRGDF LLSVNGASLA GLAHGNVLKV LHQAQLHKDA LVVIKKGMDQ PRPSARQEPP TANGKGLLSR KTIPLEPGIG RSVAVHDALC VEVLKTSAGL GLSLDGGKSS VTGDGPLVIK RVYKGGAAEQ AGIIEAGDEI LAINGKPLVG LMHFDAWNIM KSVPEGPVQL LIRKHRNSS
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