Plexin-B2 (PLXNB2)

About Plexin-B2

Plexin-B2 (PLXNB2) is a protein from Homo sapiens identified by UniProt accession O15031, 1838 residues long. MolForge cross-references it against 0 known binders and 214 disease associations.

Target properties

Protein name	Plexin-B2
UniProt accession	O15031
Gene	PLXNB2
Organism	Homo sapiens
Length	1838 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (214)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.45
cutaneous melanoma · score 0.32
hair color · score 0.32
reticulocyte count · score 0.30
reticulocyte measurement · score 0.30
cortical surface area measurement · score 0.30
blood protein measurement · score 0.26
systolic blood pressure · score 0.25
body mass index · score 0.25
hypertension · score 0.24

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O15031-F1	alphafold	PREDICTED	82.48	—

Amino-acid sequence (1838 residues)

MALQLWALTL LGLLGAGASL RPRKLDFFRS EKELNHLAVD EASGVVYLGA VNALYQLDAK LQLEQQVATG PALDNKKCTP PIEASQCHEA EMTDNVNQLL LLDPPRKRLV ECGSLFKGIC ALRALSNISL RLFYEDGSGE KSFVASNDEG VATVGLVSST GPGGDRVLFV GKGNGPHDNG IIVSTRLLDR TDSREAFEAY TDHATYKAGY LSTNTQQFVA AFEDGPYVFF VFNQQDKHPA RNRTLLARMC REDPNYYSYL EMDLQCRDPD IHAAAFGTCL AASVAAPGSG RVLYAVFSRD SRSSGGPGAG LCLFPLDKVH AKMEANRNAC YTGTREARDI FYKPFHGDIQ CGGHAPGSSK SFPCGSEHLP YPLGSRDGLR GTAVLQRGGL NLTAVTVAAE NNHTVAFLGT SDGRILKVYL TPDGTSSEYD SILVEINKRV KRDLVLSGDL GSLYAMTQDK VFRLPVQECL SYPTCTQCRD SQDPYCGWCV VEGRCTRKAE CPRAEEASHW LWSRSKSCVA VTSAQPQNMS RRAQGEVQLT VSPLPALSEE DELLCLFGES PPHPARVEGE AVICNSPSSI PVTPPGQDHV AVTIQLLLRR GNIFLTSYQY PFYDCRQAMS LEENLPCISC VSNRWTCQWD LRYHECREAS PNPEDGIVRA HMEDSCPQFL GPSPLVIPMN HETDVNFQGK NLDTVKGSSL HVGSDLLKFM EPVTMQESGT FAFRTPKLSH DANETLPLHL YVKSYGKNID SKLHVTLYNC SFGRSDCSLC RAANPDYRCA WCGGQSRCVY EALCNTTSEC PPPVITRIQP ETGPLGGGIR ITILGSNLGV QAGDIQRISV AGRNCSFQPE RYSVSTRIVC VIEAAETPFT GGVEVDVFGK LGRSPPNVQF TFQQPKPLSV EPQQGPQAGG TTLTIHGTHL DTGSQEDVRV TLNGVPCKVT KFGAQLQCVT GPQATRGQML LEVSYGGSPV PNPGIFFTYR ENPVLRAFEP LRSFASGGRS INVTGQGFSL IQRFAMVVIA EPLQSWQPPR EAESLQPMTV VGTDYVFHND TKVVFLSPAV PEEPEAYNLT VLIEMDGHRA LLRTEAGAFE YVPDPTFENF TGGVKKQVNK LIHARGTNLN KAMTLQEAEA FVGAERCTMK TLTETDLYCE PPEVQPPPKR RQKRDTTHNL PEFIVKFGSR EWVLGRVEYD TRVSDVPLSL ILPLVIVPMV VVIAVSVYCY WRKSQQAERE YEKIKSQLEG LEESVRDRCK KEFTDLMIEM EDQTNDVHEA GIPVLDYKTY TDRVFFLPSK DGDKDVMITG KLDIPEPRRP VVEQALYQFS NLLNSKSFLI NFIHTLENQR EFSARAKVYF ASLLTVALHG KLEYYTDIMH TLFLELLEQY VVAKNPKLML RRSETVVERM LSNWMSICLY QYLKDSAGEP LYKLFKAIKH QVEKGPVDAV QKKAKYTLND TGLLGDDVEY APLTVSVIVQ DEGVDAIPVK VLNCDTISQV KEKIIDQVYR GQPCSCWPRP DSVVLEWRPG STAQILSDLD LTSQREGRWK RVNTLMHYNV RDGATLILSK VGVSQQPEDS QQDLPGERHA LLEEENRVWH LVRPTDEVDE GKSKRGSVKE KERTKAITEI YLTRLLSVKG TLQQFVDNFF QSVLAPGHAV PPAVKYFFDF LDEQAEKHNI QDEDTIHIWK TNSLPLRFWV NILKNPHFIF DVHVHEVVDA SLSVIAQTFM DACTRTEHKL SRDSPSNKLL YAKEISTYKK MVEDYYKGIR QMVQVSDQDM NTHLAEISRA HTDSLNTLVA LHQLYQYTQK YYDEIINALE EDPAAQKMQL AFRLQQIAAA LENKVTDL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards