About Apoptosis-resistant E3 ubiquitin protein ligase 1
Apoptosis-resistant E3 ubiquitin protein ligase 1 (AREL1) is a protein
from Homo sapiens identified by UniProt accession
O15033, 823 residues long.
MolForge cross-references it against 0 known binders and
52 disease associations.
Target properties
| Protein name | Apoptosis-resistant E3 ubiquitin protein ligase 1 |
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| UniProt accession | O15033 |
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| Gene | AREL1 |
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| Organism | Homo sapiens |
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| Length | 823 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (52)
Diseases linked to this target (Open Targets).
- wellbeing measurement · score 0.40
- unipolar depression · score 0.40
- neuroticism measurement · score 0.36
- neurodegenerative disease · score 0.34
- depressive symptom measurement · score 0.29
- worry measurement · score 0.28
- major depressive disorder · score 0.24
- bipolar disorder · score 0.23
- clear cell renal carcinoma · score 0.18
- refractive error measurement · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O15033-F1 | alphafold | PREDICTED | 83.68 | — |
Amino-acid sequence (823 residues)
MFYVIGGITV SVVAFFFTIK FLFELAARVV SFLQNEDRER RGDRTIYDYV RGNYLDPRSC KVSWDWKDPY EVGHSMAFRV HLFYKNGQPF PAHRPVGLRV HISHVELAVE IPVTQEVLQE PNSNVVKVAF TVRKAGRYEI TVKLGGLNVA YSPYYKIFQP GMVVPSKTKI VCHFSTLVLT CGQPHTLQIV PRDEYDNPTN NSMSLRDEHN YTLSIHELGP QEEESTGVSF EKSVTSNRQT FQVFLRLTLH SRGCFHACIS YQNQPINNGE FDIIVLSEDE KNIVERNVST SGVSIYFEAY LYNATNCSST PWHLPPMHMT SSQRRPSTAV DEEDEDSPSE CHTPEKVKKP KKVYCYVSPK QFSVKEFYLK IIPWRLYTFR VCPGTKFSYL GPDPVHKLLT LVVDDGIQPP VELSCKERNI LAATFIRSLH KNIGGSETFQ DKVNFFQREL RQVHMKRPHS KVTLKVSRHA LLESSLKATR NFSISDWSKN FEVVFQDEEA LDWGGPRREW FELICKALFD TTNQLFTRFS DNNQALVHPN PNRPAHLRLK MYEFAGRLVG KCLYESSLGG AYKQLVRARF TRSFLAQIIG LRMHYKYFET DDPEFYKSKV CFILNNDMSE MELVFAEEKY NKSGQLDKVV ELMTGGAQTP VTNANKIFYL NLLAQYRLAS QVKEEVEHFL KGLNELVPEN LLAIFDENEL ELLMCGTGDI SVSDFKAHAV VVGGSWHFRE KVMRWFWTVV SSLTQEELAR LLQFTTGSSQ LPPGGFAALC PSFQIIAAPT HSTLPTAHTC FNQLCLPTYD SYEEVHRMLQ LAISEGCEGF GML
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