NEDD4-binding protein 3 (N4BP3)

About NEDD4-binding protein 3

NEDD4-binding protein 3 (N4BP3) is a protein from Homo sapiens identified by UniProt accession O15049, 544 residues long. MolForge cross-references it against 0 known binders and 10 disease associations.

Target properties

Protein name	NEDD4-binding protein 3
UniProt accession	O15049
Gene	N4BP3
Organism	Homo sapiens
Length	544 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (10)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.38
hepatocellular carcinoma · score 0.08
neoplasm · score 0.07
esophageal squamous cell carcinoma · score 0.03
prostate carcinoma · score 0.01
visceral Leishmaniasis · score 0.00
brucellosis · score 0.00
metastatic melanoma · score 0.00
Crohn's disease · score 0.00
type 2 diabetes mellitus · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O15049-F1	alphafold	PREDICTED	64.11	—

Amino-acid sequence (544 residues)

MATAPGPAGI AMGSVGSLLE RQDFSPEELR AALAGSRGSR QPDGLLRKGL GQREFLSYLH LPKKDSKSTK NTKRAPRNEP ADYATLYYRE HSRAGDFSKT SLPERGRFDK CRIRPSVFKP TAGNGKGFLS MQSLASHKGQ KLWRSNGSLH TLACHPPLSP GPRASQARAQ LLHALSLDEG GPEPEPSLSD SSSGGSFGRS PGTGPSPFSS SLGHLNHLGG SLDRASQGPK EAGPPAVLSC LPEPPPPYEF SCSSAEEMGA VLPETCEELK RGLGDEDGSN PFTQVLEERQ RLWLAELKRL YVERLHEVTQ KAERSERNLQ LQLFMAQQEQ RRLRKELRAQ QGLAPEPRAP GTLPEADPSA RPEEEARWEV CQKTAEISLL KQQLREAQAE LAQKLAEIFS LKTQLRGSRA QAQAQDAELV RLREAVRSLQ EQAPREEAPG SCETDDCKSR GLLGEAGGSE ARDSAEQLRA ELLQERLRGQ EQALRFEQER RTWQEEKERV LRYQREIQGG YMDMYRRNQA LEQELRALRE PPTPWSPRLE SSKI

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards