About Granule associated Rac and RHOG effector protein 1
Granule associated Rac and RHOG effector protein 1 (GARRE1) is a protein
from Homo sapiens identified by UniProt accession
O15063, 1070 residues long.
MolForge cross-references it against 0 known binders and
30 disease associations.
Target properties
| Protein name | Granule associated Rac and RHOG effector protein 1 |
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| UniProt accession | O15063 |
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| Gene | GARRE1 |
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| Organism | Homo sapiens |
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| Length | 1070 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (30)
Diseases linked to this target (Open Targets).
- heel bone mineral density · score 0.33
- alkaline phosphatase measurement · score 0.25
- mean corpuscular volume · score 0.20
- pulse pressure measurement · score 0.17
- Red cell distribution width · score 0.15
- attention deficit hyperactivity disorder · score 0.09
- mean corpuscular hemoglobin · score 0.08
- schizophrenia 15 · score 0.07
- attention deficit-hyperactivity disorder 8 · score 0.07
- electrocardiography · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O15063-F1 | alphafold | PREDICTED | 54.41 | — |
Amino-acid sequence (1070 residues)
MYCCSAQDSK MDYKRRFLLG GSKQKVQQHQ QYPMPELGRA LSAPLASTAT TAPLGSLTAA GSCHHAMPHT TPIADIQQGI SKYLDALNVF CRASTFLTDL FSTVFRNSHY SKAATQLKDV QEHVMEAASR LTSAIKPEIA KMLMELSAGA ANFTDQKEFS LQDIEVLGRC FLTVVQVHFQ FLTHALQKVQ PVAHSCFAEV IVPEKKNSGS GGGLSGMGHT PEVEEAVRSW RGAAEATSRL RERGCDGCLA GIEVQQLFCS QSAAIPEHQL KELNIKIDSA LQAYKIALES LGHCEYAMKA GFHLNPKAIE ASLQGCCSEA EAQQTGRRQT PPQPMQCELP TVPVQIGSHF LKGVSFNESA ADNLKLKTHT MLQLMKEAGC YNGITSRDDF PVTEVLNQVC PSTWRGACKT AVQLLFGQAG LVVVDTAQIE NKEAYAPQIS LEGSRIVVQV PSTWCLKEDP ATMSLLQRSL DPEKTLGLVD VLYTAVLDLN RWRAGREQAL PCIQIQLQRE ICDFGNQADL PSGNGNKSSG GLQKTFSKLT SRFTKKASCT SSSSSTNYSI QNTPSKNIFI AGCSEEKAKM PGNIDTRLQS ILNIGNFPRT TDPSQSAQNS SNTVANGFLM ERRENFLHGD DGKDEKGMNL PTDQEMQEVI DFLSGFNMGQ SHQGSPLVTR HNSAATAMVT EQKAGAMQPQ QPSLPVPPPP RAPQAGAHTP LTPQPGLAPQ QQSPKQQQPQ VQYYQHLLQP IGPQQPPPQP RAPGKWVHGS SQQPAQAVGA GLSPLGQWPG ISDLSSDLYS LGLVSSYMDN VMSEVLGQKP QGPRNNTWPN RDQSDGVFGM LGEILPFDPA VGSDPEFARY VAGVSQAMQQ KRQAQHGRRP GNPRGNWPPM DDAHRTWPFP EFFTEGDGLH GGWSGAQGDS ASSSDETSSA NGDSLFSMFS GPDLVAAVKQ RRKHSSGEQD TSTLPSPPLL TTVEDVNQDN KTKTWPPKAP WQHPSPLPST LPSPSAPLYA VTSPGSQWND TMQMLQSPVW AATNDCSAAA FSYVQTPPQP PPPPAHKAAP KGFKAFPGKG ERRPAYLPQY
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