About Kinesin-like protein KIF3B
Kinesin-like protein KIF3B (KIF3B) is a protein
from Homo sapiens identified by UniProt accession
O15066, 747 residues long.
MolForge cross-references it against 0 known binders and
82 disease associations.
Target properties
| Protein name | Kinesin-like protein KIF3B |
|---|
| UniProt accession | O15066 |
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| Gene | KIF3B |
|---|
| Organism | Homo sapiens |
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| Length | 747 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
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Disease associations (82)
Diseases linked to this target (Open Targets).
- retinitis pigmentosa 89 · score 0.49
- neurodegenerative disease · score 0.37
- azoospermia · score 0.33
- FEV/FVC ratio · score 0.28
- blood protein measurement · score 0.24
- Hepatic fibrosis · score 0.23
- postaxial polydactyly · score 0.23
- ovarian cancer · score 0.18
- breast adenocarcinoma · score 0.18
- monocyte percentage of leukocytes · score 0.17
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O15066-F1 | alphafold | PREDICTED | 76.50 | — |
Amino-acid sequence (747 residues)
MSKLKSSESV RVVVRCRPMN GKEKAASYDK VVDVDVKLGQ VSVKNPKGTA HEMPKTFTFD AVYDWNAKQF ELYDETFRPL VDSVLQGFNG TIFAYGQTGT GKTYTMEGIR GDPEKRGVIP NSFDHIFTHI SRSQNQQYLV RASYLEIYQE EIRDLLSKDQ TKRLELKERP DTGVYVKDLS SFVTKSVKEI EHVMNVGNQN RSVGATNMNE HSSRSHAIFV ITIECSEVGL DGENHIRVGK LNLVDLAGSE RQAKTGAQGE RLKEATKINL SLSALGNVIS ALVDGKSTHI PYRDSKLTRL LQDSLGGNAK TVMVANVGPA SYNVEETLTT LRYANRAKNI KNKPRVNEDP KDALLREFQE EIARLKAQLE KRSIGRRKRR EKRREGGGSG GGGEEEEEEG EEGEEEGDDK DDYWREQQEK LEIEKRAIVE DHSLVAEEKM RLLKEKEKKM EDLRREKDAA EMLGAKIKAM ESKLLVGGKN IVDHTNEQQK ILEQKRQEIA EQKRREREIQ QQMESRDEET LELKETYSSL QQEVDIKTKK LKKLFSKLQA VKAEIHDLQE EHIKERQELE QTQNELTREL KLKHLIIENF IPLEEKSKIM NRAFFDEEED HWKLHPITRL ENQQMMKRPV SAVGYKRPLS QHARMSMMIR PEARYRAENI VLLELDMPSR TTRDYEGPAI APKVQAALDA ALQDEDEIQV DASSFESTAN KKSKARPKSG RKSGSSSSSS GTPASQLYPQ SRGLVPK
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