About NAC-alpha domain-containing protein 1
NAC-alpha domain-containing protein 1 (NACAD) is a protein
from Homo sapiens identified by UniProt accession
O15069, 1562 residues long.
MolForge cross-references it against 0 known binders and
47 disease associations.
Target properties
| Protein name | NAC-alpha domain-containing protein 1 |
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| UniProt accession | O15069 |
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| Gene | NACAD |
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| Organism | Homo sapiens |
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| Length | 1562 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (47)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.35
- platelet count · score 0.27
- colorectal cancer · score 0.14
- smoking status measurement · score 0.13
- eosinophil count · score 0.12
- colorectal adenoma · score 0.12
- platelet crit · score 0.12
- mitochondrial DNA measurement · score 0.11
- eosinophil percentage of leukocytes · score 0.10
- neutrophil count · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O15069-F1 | alphafold | PREDICTED | 39.69 | — |
Amino-acid sequence (1562 residues)
MPGEAARAEL LLPEADRPGP RTDLSCDAAA ATTILGGDRR EPCALTPGPS HLALTFLPSK PGARPQPEGA SWDAGPGGAP SAWADPGEGG PSPMLLPEGL SSQALSTEAP LPATLEPRIV MGEETCQALL SPRAARTALR DQEGGHASPD PPPELCSQGD LSVPSPPPDP DSFFTPPSTP TKTTYALLPA CGPHGDARDS EAELRDELLD SPPASPSGSY ITADGDSWAS SPSCSLSLLA PAEGLDFPSG WGLSPQGSMV DERELHPAGT PEPPSSESSL SADSSSSWGQ EGHFFDLDFL ANDPMIPAAL LPFQGSLIFQ VEAVEVTPLS PEEEEEEAVA DPDPGGDLAG EGEEDSTSAS FLQSLSDLSI TEGMDEAFAF RDDTSAASSD SDSASYAEAD DERLYSGEPH AQATLLQDSV QKTEEESGGG AKGLQAQDGT VSWAVEAAPQ TSDRGAYLSQ RQELISEVTE EGLALGQEST ATVTPHTLQV APGLQVEVAT RVTPQAGEEE TDSTAGQESA AMAMPQPSQE GISEILGQES VTAEKLPTPQ EETSLTLCPD SPQNLKEEGG LDLPSGRKPV AAATIVPRQA KEDLTLPQDS AMTPPLPLQD TDLSSAPKPV AAATIVSQQA EEGLTLPQDS VMTPPLPLQD TELSSAPKPV AAATLVSQQA EEGLTLPQDS AMTPPLPLQD TDLSSAPKPV AAATLVSQQA EEGLTLPQDS AMTPPLPLQD TDLSSAPKPV AAATLVSQQA EEGLTLPQDS AMTPPLPLQD TDLSSAPKPV AAATIVSQQA EEGLTLPQDS AMTPPLPLQD TDLSSAPKPV AAATIVSQQA EEGLTLPQDS AMTPPLPLQD TDLSSAPKPV AAATPVSQQA EEGLTLPQDS AMTPPLPLQD TDLSSAPKPV AAATPVSQQA EEGLTLPQDS AMTAPLPLQD TGPTSGPEPL AVATPQTLQA EAGCAPGTEP VATMAQQEVG EALGPRPAPE EKNAALPTVP EPAALDQVQQ DDPQPAAEAG TPWAAQEDAD STLGMEALSL PEPASGAGEE IAEALSRPGR EACLEARAHT GDGAKPDSPQ KETLEVENQQ EGGLKPLAQE HGPRSALGGA REVPDAPPAA CPEVSQARLL SPAREERGLS GKSTPEPTLP SAVATEASLD SCPESSVGAV SSLDRGCPDA PAPTSAPTSQ QPEPVLGLGS VEQPHEVPSV LGTPLLQPPE NLAKGQPSTP VDRPLGPDPS APGTLAGAAL PPLEPPAPCL CQDPQEDSVE DEEPPGSLGL PPPQAGVQPA AAAVSGTTQP LGTGPRVSLS PHSPLLSPKV ASMDAKDLAL QILPPCQVPP PSGPQSPAGP QGLSAPEQQE DEDSLEEDSP RALGSGQHSD SHGESSAELD EQDILAPQTV QCPAQAPAGG SEETIAKAKQ SRSEKKARKA MSKLGLRQIQ GVTRITIQKS KNILFVIAKP DVFKSPASDT YVVFGEAKIE DLSQQVHKAA AEKFKVPSEP SALVPESAPR PRVRLECKEE EEEEEEEVDE AGLELRDIEL VMAQANVSRA KAVRALRDNH SDIVNAIMEL TM
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