About ERC protein 2
ERC protein 2 (ERC2) is a protein
from Homo sapiens identified by UniProt accession
O15083, 957 residues long.
MolForge cross-references it against 0 known binders and
176 disease associations.
Target properties
| Protein name | ERC protein 2 |
|---|
| UniProt accession | O15083 |
|---|
| Gene | ERC2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 957 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (176)
Diseases linked to this target (Open Targets).
- heel bone mineral density · score 0.46
- bone quantitative ultrasound measurement · score 0.42
- FEV/FVC ratio · score 0.40
- body height · score 0.37
- electrocardiography · score 0.34
- mean platelet volume · score 0.33
- bone density · score 0.33
- peak expiratory flow · score 0.32
- circadian rhythm · score 0.31
- body mass index · score 0.30
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O15083-F1 | alphafold | PREDICTED | 73.62 | — |
Amino-acid sequence (957 residues)
MYGSARTITN LEGSPSRSPR LPRSPRLGHR RTSSGGGGGT GKTLSMENIQ SLNAAYATSG PMYLSDHEGV ASTTYPKGTM TLGRATNRAV YGGRVTAMGS SPNIASAGLS HTDVLSYTDQ HGGLTGSSHH HHHQVPSMLR QVRDSTMLDL QAQLKELQRE NDLLRKELDI KDSKLGSSMN SIKTFWSPEL KKERVLRKEE AARMSVLKEQ MRVSHEENQH LQLTIQALQD ELRTQRDLNH LLQQESGNRG AEHFTIELTE ENFRRLQAEH DRQAKELFLL RKTLEEMELR IETQKQTLNA RDESIKKLLE MLQSKGLPSK SLEDDNERTR RMAEAESQVS HLEVILDQKE KENIHLREEL HRRSQLQPEP AKTKALQTVI EMKDTKIASL ERNIRDLEDE IQMLKANGVL NTEDREEEIK QIEVYKSHSK FMKTKIDQLK QELSKKESEL LALQTKLETL SNQNSDCKQH IEVLKESLTA KEQRAAILQT EVDALRLRLE EKESFLNKKT KQLQDLTEEK GTLAGEIRDM KDMLEVKERK INVLQKKIEN LQEQLRDKDK QLTNLKDRVK SLQTDSSNTD TALATLEEAL SEKERIIERL KEQRERDDRE RLEEIESFRK ENKDLKEKVN ALQAELTEKE SSLIDLKEHA SSLASAGLKR DSKLKSLEIA IEQKKEECSK LEAQLKKAHN IEDDSRMNPE FADQIKQLDK EASYYRDECG KAQAEVDRLL EILKEVENEK NDKDKKIAEL ESLTLRHMKD QNKKVANLKH NQQLEKKKNA QLLEEVRRRE DSMADNSQHL QIEELMNALE KTRQELDATK ARLASTQQSL AEKEAHLANL RIERRKQLEE ILEMKQEALL AAISEKDANI ALLELSASKK KKTQEEVMAL KREKDRLVHQ LKQQTQNRMK LMADNYDDDH HHYHHHHHHH HHRSPGRSQH SNHRPSPDQD DEEGIWA
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