About Mitochondrial ribonuclease P catalytic subunit
Mitochondrial ribonuclease P catalytic subunit (PRORP) is a protein
from Homo sapiens identified by UniProt accession
O15091, 583 residues long.
MolForge cross-references it against 0 known binders and
76 disease associations.
Target properties
| Protein name | Mitochondrial ribonuclease P catalytic subunit |
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| UniProt accession | O15091 |
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| Gene | PRORP |
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| Organism | Homo sapiens |
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| Length | 583 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
|---|
Disease associations (76)
Diseases linked to this target (Open Targets).
- combined oxidative phosphorylation deficiency 54 · score 0.60
- Childhood onset sensorineural hearing impairment · score 0.37
- Leukoencephalopathy · score 0.35
- lean body mass · score 0.35
- Global developmental delay · score 0.32
- lactic acidosis · score 0.32
- Feeding difficulties · score 0.32
- Hypertonia · score 0.32
- Microcephaly · score 0.32
- Perrault syndrome 1 · score 0.32
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O15091-F1 | alphafold | PREDICTED | 78.91 | — |
Amino-acid sequence (583 residues)
MTFYLFGIRS FPKLWKSPYL GLGPGHSYVS LFLADRCGIR NQQRLFSLKT MSPQNTKATN LIAKARYLRK DEGSNKQVYS VPHFFLAGAA KERSQMNSQT EDHALAPVRN TIQLPTQPLN SEEWDKLKED LKENTGKTSF ESWIISQMAG CHSSIDVAKS LLAWVAAKNN GIVSYDLLVK YLYLCVFHMQ TSEVIDVFEI MKARYKTLEP RGYSLLIRGL IHSDRWREAL LLLEDIKKVI TPSKKNYNDC IQGALLHQDV NTAWNLYQEL LGHDIVPMLE TLKAFFDFGK DIKDDNYSNK LLDILSYLRN NQLYPGESFA HSIKTWFESV PGKQWKGQFT TVRKSGQCSG CGKTIESIQL SPEEYECLKG KIMRDVIDGG DQYRKTTPQE LKRFENFIKS RPPFDVVIDG LNVAKMFPKV RESQLLLNVV SQLAKRNLRL LVLGRKHMLR RSSQWSRDEM EEVQKQASCF FADDISEDDP FLLYATLHSG NHCRFITRDL MRDHKACLPD AKTQRLFFKW QQGHQLAIVN RFPGSKLTFQ RILSYDTVVQ TTGDSWHIPY DEDLVERCSC EVPTKWLCLH QKT
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