About Inhibitor of nuclear factor kappa-B kinase subunit alpha
Inhibitor of nuclear factor kappa-B kinase subunit alpha (CHUK) is a protein
from Homo sapiens identified by UniProt accession
O15111, 745 residues long.
MolForge cross-references it against 0 known binders and
749 disease associations.
Target properties
| Protein name | Inhibitor of nuclear factor kappa-B kinase subunit alpha |
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| UniProt accession | O15111 |
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| Gene | CHUK |
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| Organism | Homo sapiens |
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| Length | 745 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (9)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (749)
Diseases linked to this target (Open Targets).
- cocoon syndrome · score 0.67
- COVID-19 · score 0.46
- Bartsocas-Papas syndrome 1 · score 0.38
- neurodegenerative disease · score 0.37
- neuroinflammatory disorder · score 0.37
- glioblastoma multiforme · score 0.29
- breast adenocarcinoma · score 0.29
- ovarian cancer · score 0.28
- lung adenocarcinoma · score 0.22
- genetic disorder · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O15111-F1 | alphafold | PREDICTED | 83.83 | — |
Amino-acid sequence (745 residues)
MERPPGLRPG AGGPWEMRER LGTGGFGNVC LYQHRELDLK IAIKSCRLEL STKNRERWCH EIQIMKKLNH ANVVKACDVP EELNILIHDV PLLAMEYCSG GDLRKLLNKP ENCCGLKESQ ILSLLSDIGS GIRYLHENKI IHRDLKPENI VLQDVGGKII HKIIDLGYAK DVDQGSLCTS FVGTLQYLAP ELFENKPYTA TVDYWSFGTM VFECIAGYRP FLHHLQPFTW HEKIKKKDPK CIFACEEMSG EVRFSSHLPQ PNSLCSLVVE PMENWLQLML NWDPQQRGGP VDLTLKQPRC FVLMDHILNL KIVHILNMTS AKIISFLLPP DESLHSLQSR IERETGINTG SQELLSETGI SLDPRKPASQ CVLDGVRGCD SYMVYLFDKS KTVYEGPFAS RSLSDCVNYI VQDSKIQLPI IQLRKVWAEA VHYVSGLKED YSRLFQGQRA AMLSLLRYNA NLTKMKNTLI SASQQLKAKL EFFHKSIQLD LERYSEQMTY GISSEKMLKA WKEMEEKAIH YAEVGVIGYL EDQIMSLHAE IMELQKSPYG RRQGDLMESL EQRAIDLYKQ LKHRPSDHSY SDSTEMVKII VHTVQSQDRV LKELFGHLSK LLGCKQKIID LLPKVEVALS NIKEADNTVM FMQGKRQKEI WHLLKIACTQ SSARSLVGSS LEGAVTPQTS AWLPPTSAEH DHSLSCVVTP QDGETSAQMI EENLNCLGHL STIIHEANEE QGNSMMNLDW SWLTE
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