Sphingolipid delta(4)-desaturase DES1 (DEGS1)

About Sphingolipid delta(4)-desaturase DES1

Sphingolipid delta(4)-desaturase DES1 (DEGS1) is a protein from Homo sapiens identified by UniProt accession O15121, 323 residues long. MolForge cross-references it against 0 known binders and 88 disease associations.

Target properties

Protein name	Sphingolipid delta(4)-desaturase DES1
UniProt accession	O15121
Gene	DEGS1
Organism	Homo sapiens
Length	323 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (88)

Diseases linked to this target (Open Targets).

leukodystrophy · score 0.72
genetic disorder · score 0.37
Global developmental delay · score 0.37
Seizure · score 0.37
mean platelet volume · score 0.35
erythrocyte count · score 0.34
neurodegenerative disease · score 0.28
mean reticulocyte volume · score 0.23
monocyte count · score 0.22
red blood cell density measurement · score 0.14

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O15121-F1	alphafold	PREDICTED	96.83	—

Amino-acid sequence (323 residues)

MGSRVSREDF EWVYTDQPHA DRRREILAKY PEIKSLMKPD PNLIWIIIMM VLTQLGAFYI VKDLDWKWVI FGAYAFGSCI NHSMTLAIHE IAHNAAFGNC KAMWNRWFGM FANLPIGIPY SISFKRYHMD HHRYLGADGV DVDIPTDFEG WFFCTAFRKF IWVILQPLFY AFRPLFINPK PITYLEVINT VAQVTFDILI YYFLGIKSLV YMLAASLLGL GLHPISGHFI AEHYMFLKGH ETYSYYGPLN LLTFNVGYHN EHHDFPNIPG KSLPLVRKIA AEYYDNLPHY NSWIKVLYDF VMDDTISPYS RMKRHQKGEM VLE

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards