About Angiopoietin-2
Angiopoietin-2 (ANGPT2) is a protein
from Homo sapiens identified by UniProt accession
O15123, 496 residues long.
MolForge cross-references it against 0 known binders and
615 disease associations.
Target properties
| Protein name | Angiopoietin-2 |
|---|
| UniProt accession | O15123 |
|---|
| Gene | ANGPT2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 496 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (615)
Diseases linked to this target (Open Targets).
- diabetic macular edema · score 0.54
- wet macular degeneration · score 0.51
- diastolic blood pressure · score 0.42
- heel bone mineral density · score 0.41
- intraocular pressure measurement · score 0.38
- Non-immune hydrops fetalis · score 0.38
- systolic blood pressure · score 0.38
- macular retinal edema · score 0.37
- macrovascular complications of diabetes · score 0.37
- ocular vascular disease · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O15123-F1 | alphafold | PREDICTED | 83.85 | — |
Amino-acid sequence (496 residues)
MWQIVFFTLS CDLVLAAAYN NFRKSMDSIG KKQYQVQHGS CSYTFLLPEM DNCRSSSSPY VSNAVQRDAP LEYDDSVQRL QVLENIMENN TQWLMKLENY IQDNMKKEMV EIQQNAVQNQ TAVMIEIGTN LLNQTAEQTR KLTDVEAQVL NQTTRLELQL LEHSLSTNKL EKQILDQTSE INKLQDKNSF LEKKVLAMED KHIIQLQSIK EEKDQLQVLV SKQNSIIEEL EKKIVTATVN NSVLQKQQHD LMETVNNLLT MMSTSNSAKD PTVAKEEQIS FRDCAEVFKS GHTTNGIYTL TFPNSTEEIK AYCDMEAGGG GWTIIQRRED GSVDFQRTWK EYKVGFGNPS GEYWLGNEFV SQLTNQQRYV LKIHLKDWEG NEAYSLYEHF YLSSEELNYR IHLKGLTGTA GKISSISQPG NDFSTKDGDN DKCICKCSQM LTGGWWFDAC GPSNLNGMYY PQRQNTNKFN GIKWYYWKGS GYSLKATTMM IRPADF
Explore Angiopoietin-2 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets