Pro-FMRFamide-related neuropeptide FF (NPFF)

About Pro-FMRFamide-related neuropeptide FF

Pro-FMRFamide-related neuropeptide FF (NPFF) is a protein from Homo sapiens identified by UniProt accession O15130, 113 residues long. MolForge cross-references it against 0 known binders and 58 disease associations.

Target properties

Protein name	Pro-FMRFamide-related neuropeptide FF
UniProt accession	O15130
Gene	NPFF
Organism	Homo sapiens
Length	113 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (58)

Diseases linked to this target (Open Targets).

cutaneous melanoma · score 0.18
attention deficit hyperactivity disorder · score 0.09
schizophrenia 15 · score 0.07
attention deficit-hyperactivity disorder 8 · score 0.07
Tourette syndrome · score 0.06
Phelan-McDermid syndrome · score 0.05
Spinal cord injury · score 0.05
autism · score 0.05
joint disease · score 0.05
X-linked non-syndromic intellectual disability · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O15130-F1	alphafold	PREDICTED	63.70	—

Amino-acid sequence (113 residues)

MDSRQAAALL VLLLLIDGGC AEGPGGQQED QLSAEEDSEP LPPQDAQTSG SLLHYLLQAM ERPGRSQAFL FQPQRFGRNT QGSWRNEWLS PRAGEGLNSQ FWSLAAPQRF GKK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards