Importin subunit alpha-6 (KPNA5)

About Importin subunit alpha-6

Importin subunit alpha-6 (KPNA5) is a protein from Homo sapiens identified by UniProt accession O15131, 539 residues long. MolForge cross-references it against 0 known binders and 22 disease associations.

Target properties

Protein name	Importin subunit alpha-6
UniProt accession	O15131
Gene	KPNA5
Organism	Homo sapiens
Length	539 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (22)

Diseases linked to this target (Open Targets).

influenza · score 0.46
metabolite measurement · score 0.10
eosinophil count · score 0.02
COVID-19 · score 0.02
lung adenocarcinoma · score 0.01
ovarian carcinoma · score 0.01
Sepsis · score 0.01
septic shock · score 0.01
pachyonychia congenita · score 0.01
colorectal cancer · score 0.01

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O15131-F1	alphafold	PREDICTED	85.89	—

Amino-acid sequence (539 residues)

MDAMASPGKD NYRMKSYKNK ALNPQEMRRR REEEGIQLRK QKREEQLFKR RNVYLPRNDE SMLESPIQDP DISSTVPIPE EEVVTTDMVQ MIFSNNADQQ LTATQKFRKL LSKEPNPPID QVIQKPGVVQ RFVKFLERNE NCTLQFEAAW ALTNIASGTF LHTKVVIETG AVPIFIKLLN SEHEDVQEQA VWALGNIAGD NAECRDFVLN CEILPPLLEL LTNSNRLTTT RNAVWALSNL CRGKNPPPNF SKVSPCLNVL SRLLFSSDPD VLADVCWALS YLSDGPNDKI QAVIDSGVCR RLVELLMHND YKVVSPALRA VGNIVTGDDI QTQVILNCSA LPCLLHLLSS PKESIRKEAC WTVSNITAGN RAQIQAVIDA NIFPVLIEIL QKAEFRTRKE AAWAITNATS GGTPEQIRYL VALGCIKPLC DLLTVMDSKI VQVALNGLEN ILRLGEQESK QNGIGINPYC ALIEEAYGLD KIEFLQSHEN QEIYQKAFDL IEHYFGVEED DPSIVPQVDE NQQQFIFQQQ EAPMDGFQL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards