Actin-related protein 2/3 complex subunit 1B (ARPC1B)

About Actin-related protein 2/3 complex subunit 1B

Actin-related protein 2/3 complex subunit 1B (ARPC1B) is a protein from Homo sapiens identified by UniProt accession O15143, 372 residues long. MolForge cross-references it against 0 known binders and 251 disease associations.

Target properties

Protein name	Actin-related protein 2/3 complex subunit 1B
UniProt accession	O15143
Gene	ARPC1B
Organism	Homo sapiens
Length	372 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (251)

Diseases linked to this target (Open Targets).

platelet abnormalities with eosinophilia and immune-mediated inflammatory disease · score 0.74
combined immunodeficiency · score 0.43
Combined T and B cell immunodeficiency · score 0.43
neuroinflammatory disorder · score 0.40
cutaneous Leishmaniasis · score 0.37
neurodegenerative disease · score 0.34
genetic disorder · score 0.19
endometrial cancer · score 0.18
alcohol consumption measurement · score 0.18
breast adenocarcinoma · score 0.18

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O15143-F1	alphafold	PREDICTED	92.42	—

Amino-acid sequence (372 residues)

MAYHSFLVEP ISCHAWNKDR TQIAICPNNH EVHIYEKSGA KWTKVHELKE HNGQVTGIDW APESNRIVTC GTDRNAYVWT LKGRTWKPTL VILRINRAAR CVRWAPNENK FAVGSGSRVI SICYFEQEND WWVCKHIKKP IRSTVLSLDW HPNNVLLAAG SCDFKCRIFS AYIKEVEERP APTPWGSKMP FGELMFESSS SCGWVHGVCF SASGSRVAWV SHDSTVCLAD ADKKMAVATL ASETLPLLAL TFITDNSLVA AGHDCFPVLF TYDAAAGMLS FGGRLDVPKQ SSQRGLTARE RFQNLDKKAS SEGGTAAGAG LDSLHKNSVS QISVLSGGKA KCSQFCTTGM DGGMSIWDVK SLESALKDLK IK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards