Actin-related protein 2/3 complex subunit 2 (ARPC2)

About Actin-related protein 2/3 complex subunit 2

Actin-related protein 2/3 complex subunit 2 (ARPC2) is a protein from Homo sapiens identified by UniProt accession O15144, 300 residues long. MolForge cross-references it against 0 known binders and 110 disease associations.

Target properties

Protein name	Actin-related protein 2/3 complex subunit 2
UniProt accession	O15144
Gene	ARPC2
Organism	Homo sapiens
Length	300 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (110)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.56
neutrophil count · score 0.45
leukocyte count · score 0.44
lymphocyte percentage of leukocytes · score 0.42
neutrophil percentage of leukocytes · score 0.42
cutaneous Leishmaniasis · score 0.37
monocyte percentage of leukocytes · score 0.34
mean platelet volume · score 0.32
platelet component distribution width · score 0.31
platelet count · score 0.31

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O15144-F1	alphafold	PREDICTED	93.97	—

Amino-acid sequence (300 residues)

MILLEVNNRI IEETLALKFE NAAAGNKPEA VEVTFADFDG VLYHISNPNG DKTKVMVSIS LKFYKELQAH GADELLKRVY GSFLVNPESG YNVSLLYDLE NLPASKDSIV HQAGMLKRNC FASVFEKYFQ FQEEGKEGEN RAVIHYRDDE TMYVESKKDR VTVVFSTVFK DDDDVVIGKV FMQEFKEGRR ASHTAPQVLF SHREPPLELK DTDAAVGDNI GYITFVLFPR HTNASARDNT INLIHTFRDY LHYHIKCSKA YIHTRMRAKT SDFLKVLNRA RPDAEKKEMK TITGKTFSSR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards