Protein Mdm4 (MDM4)

About Protein Mdm4

Protein Mdm4 (MDM4) is a protein from Homo sapiens identified by UniProt accession O15151, 490 residues long. MolForge cross-references it against 0 known binders and 377 disease associations.

Target properties

Protein name	Protein Mdm4
UniProt accession	O15151
Gene	MDM4
Organism	Homo sapiens
Length	490 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (377)

Diseases linked to this target (Open Targets).

bone marrow failure syndrome 6 · score 0.47
neurodegenerative disease · score 0.43
prostate carcinoma · score 0.43
vital capacity · score 0.37
Hepatobiliary Neoplasm · score 0.37
bile duct carcinoma · score 0.37
lymphoid neoplasm · score 0.37
nodular melanoma · score 0.37
gastric carcinoma · score 0.37
Ovarian Endometrioid Adenocarcinoma with Squamous Differentiation · score 0.37

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O15151-F1	alphafold	PREDICTED	60.10	—

Amino-acid sequence (490 residues)

MTSFSTSAQC STSDSACRIS PGQINQVRPK LPLLKILHAA GAQGEMFTVK EVMHYLGQYI MVKQLYDQQE QHMVYCGGDL LGELLGRQSF SVKDPSPLYD MLRKNLVTLA TATTDAAQTL ALAQDHSMDI PSQDQLKQSA EESSTSRKRT TEDDIPTLPT SEHKCIHSRE DEDLIENLAQ DETSRLDLGF EEWDVAGLPW WFLGNLRSNY TPRSNGSTDL QTNQDVGTAI VSDTTDDLWF LNESVSEQLG VGIKVEAADT EQTSEEVGKV SDKKVIEVGK NDDLEDSKSL SDDTDVEVTS EDEWQCTECK KFNSPSKRYC FRCWALRKDW YSDCSKLTHS LSTSDITAIP EKENEGNDVP DCRRTISAPV VRPKDAYIKK ENSKLFDPCN SVEFLDLAHS SESQETISSM GEQLDNLSEQ RTDTENMEDC QNLLKPCSLC EKRPRDGNII HGRTGHLVTC FHCARRLKKA GASCPICKKE IQLVIKVFIA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards