About DNA-directed RNA polymerases I and III subunit RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1 (POLR1C) is a protein
from Homo sapiens identified by UniProt accession
O15160, 346 residues long.
MolForge cross-references it against 0 known binders and
96 disease associations.
Target properties
| Protein name | DNA-directed RNA polymerases I and III subunit RPAC1 |
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| UniProt accession | O15160 |
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| Gene | POLR1C |
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| Organism | Homo sapiens |
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| Length | 346 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (96)
Diseases linked to this target (Open Targets).
- Treacher-Collins syndrome · score 0.73
- Hypomyelinating leukodystrophy with or without oligondontia and/or hypogonadism · score 0.71
- Hypomyelination - hypogonadotropic hypogonadism - hypodontia · score 0.57
- genetic disorder · score 0.41
- leukodystrophy · score 0.37
- hypomyelination-hypogonadotropic hypogonadism-hypodontia syndrome · score 0.37
- Hearing impairment · score 0.15
- breast adenocarcinoma · score 0.11
- early-onset non-syndromic cataract · score 0.10
- hereditary hyperferritinemia with congenital cataracts · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O15160-F1 | alphafold | PREDICTED | 92.11 | — |
Amino-acid sequence (346 residues)
MAASQAVEEM RSRVVLGEFG VRNVHTTDFP GNYSGYDDAW DQDRFEKNFR VDVVHMDENS LEFDMVGIDA AIANAFRRIL LAEVPTMAVE KVLVYNNTSI VQDEILAHRL GLIPIHADPR LFEYRNQGDE EGTEIDTLQF RLQVRCTRNP HAAKDSSDPN ELYVNHKVYT RHMTWIPLGN QADLFPEGTI RPVHDDILIA QLRPGQEIDL LMHCVKGIGK DHAKFSPVAT ASYRLLPDIT LLEPVEGEAA EELSRCFSPG VIEVQEVQGK KVARVANPRL DTFSREIFRN EKLKKVVRLA RVRDHYIFSV ESTGVLPPDV LVSEAIKVLM GKCRRFLDEL DAVQMD
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