About Phospholipid scramblase 1
Phospholipid scramblase 1 (PLSCR1) is a protein
from Homo sapiens identified by UniProt accession
O15162, 318 residues long.
MolForge cross-references it against 0 known binders and
189 disease associations.
Target properties
| Protein name | Phospholipid scramblase 1 |
|---|
| UniProt accession | O15162 |
|---|
| Gene | PLSCR1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 318 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (189)
Diseases linked to this target (Open Targets).
- gut microbiome measurement · score 0.21
- systemic lupus erythematosus · score 0.10
- acute myeloid leukemia · score 0.10
- diabetic eye disease · score 0.08
- Mantle cell lymphoma · score 0.08
- neoplasm · score 0.07
- colorectal carcinoma · score 0.06
- liver cancer · score 0.06
- Blackfan-Diamond anemia · score 0.06
- Romano-Ward syndrome · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O15162-F1 | alphafold | PREDICTED | 69.81 | — |
Amino-acid sequence (318 residues)
MDKQNSQMNA SHPETNLPVG YPPQYPPTAF QGPPGYSGYP GPQVSYPPPP AGHSGPGPAG FPVPNQPVYN QPVYNQPVGA AGVPWMPAPQ PPLNCPPGLE YLSQIDQILI HQQIELLEVL TGFETNNKYE IKNSFGQRVY FAAEDTDCCT RNCCGPSRPF TLRIIDNMGQ EVITLERPLR CSSCCCPCCL QEIEIQAPPG VPIGYVIQTW HPCLPKFTIQ NEKREDVLKI SGPCVVCSCC GDVDFEIKSL DEQCVVGKIS KHWTGILREA FTDADNFGIQ FPLDLDVKMK AVMIGACFLI DFMFFESTGS QEQKSGVW
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