About Membrane-associated progesterone receptor component 2
Membrane-associated progesterone receptor component 2 (PGRMC2) is a protein
from Homo sapiens identified by UniProt accession
O15173, 223 residues long.
MolForge cross-references it against 0 known binders and
54 disease associations.
Target properties
| Protein name | Membrane-associated progesterone receptor component 2 |
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| UniProt accession | O15173 |
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| Gene | PGRMC2 |
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| Organism | Homo sapiens |
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| Length | 223 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
|---|
Disease associations (54)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.49
- Red cell distribution width · score 0.30
- mean corpuscular volume · score 0.26
- mean reticulocyte volume · score 0.24
- type 2 diabetes mellitus · score 0.24
- reticulocyte count · score 0.23
- reticulocyte measurement · score 0.13
- Hirschsprung disease · score 0.11
- platelet count · score 0.10
- joint disease · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O15173-F1 | alphafold | PREDICTED | 77.56 | — |
Amino-acid sequence (223 residues)
MAAGDGDVKL GTLGSGSESS NDGGSESPGD AGAAAEGGGW AAAALALLTG GGEMLLNVAL VALVLLGAYR LWVRWGRRGL GAGAGAGEES PATSLPRMKK RDFSLEQLRQ YDGSRNPRIL LAVNGKVFDV TKGSKFYGPA GPYGIFAGRD ASRGLATFCL DKDALRDEYD DLSDLNAVQM ESVREWEMQF KEKYDYVGRL LKPGEEPSEY TDEEDTKDHN KQD
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