T-box transcription factor T (TBXT)

About T-box transcription factor T

T-box transcription factor T (TBXT) is a protein from Homo sapiens identified by UniProt accession O15178, 435 residues long. MolForge cross-references it against 0 known binders and 995 disease associations.

Target properties

Protein name	T-box transcription factor T
UniProt accession	O15178
Gene	TBXT
Organism	Homo sapiens
Length	435 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (995)

Diseases linked to this target (Open Targets).

sacral agenesis-abnormal ossification of the vertebral bodies-persistent notochordal canal syndrome · score 0.51
spina bifida · score 0.47
body height · score 0.38
chordoma · score 0.37
sitting height measurement · score 0.32
lean body mass · score 0.27
appendicular lean mass · score 0.26
urate measurement · score 0.25
uric acid measurement · score 0.23
creatinine measurement · score 0.23

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O15178-F1	alphafold	PREDICTED	64.51	—

Amino-acid sequence (435 residues)

MSSPGTESAG KSLQYRVDHL LSAVENELQA GSEKGDPTER ELRVGLEESE LWLRFKELTN EMIVTKNGRR MFPVLKVNVS GLDPNAMYSF LLDFVAADNH RWKYVNGEWV PGGKPEPQAP SCVYIHPDSP NFGAHWMKAP VSFSKVKLTN KLNGGGQIML NSLHKYEPRI HIVRVGGPQR MITSHCFPET QFIAVTAYQN EEITALKIKY NPFAKAFLDA KERSDHKEMM EEPGDSQQPG YSQWGWLLPG TSTLCPPANP HPQFGGALSL PSTHSCDRYP TLRSHRSSPY PSPYAHRNNS PTYSDNSPAC LSMLQSHDNW SSLGMPAHPS MLPVSHNASP PTSSSQYPSL WSVSNGAVTP GSQAAAVSNG LGAQFFRGSP AHYTPLTHPV SAPSSSGSPL YEGAAAATDI VDSQYDAAAQ GRLIASWTPV SPPSM

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards