About Zinc finger and BTB domain-containing protein 22
Zinc finger and BTB domain-containing protein 22 (ZBTB22) is a protein
from Homo sapiens identified by UniProt accession
O15209, 634 residues long.
MolForge cross-references it against 0 known binders and
45 disease associations.
Target properties
| Protein name | Zinc finger and BTB domain-containing protein 22 |
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| UniProt accession | O15209 |
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| Gene | ZBTB22 |
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| Organism | Homo sapiens |
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| Length | 634 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (45)
Diseases linked to this target (Open Targets).
- body height · score 0.11
- body mass index · score 0.09
- self reported educational attainment · score 0.06
- cyst · score 0.05
- gait measurement · score 0.05
- multiple symmetric lipomatosis · score 0.04
- Familial partial lipodystrophy, Köbberling type · score 0.04
- familial partial lipodystrophy, Kobberling type · score 0.04
- age at menopause · score 0.04
- Hyperlipoproteinemia type 1 · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O15209-F1 | alphafold | PREDICTED | 51.20 | — |
Amino-acid sequence (634 residues)
MEPSPLSPSG AALPLPLSLA PPPLPLPAAA VVHVSFPEVT SALLESLNQQ RLQGQLCDVS IRVQGREFRA HRAVLAASSP YFHDQVLLKG MTSISLPSVM DPGAFETVLA SAYTGRLSMA AADIVNFLTV GSVLQMWHIV DKCTELLREG RASATTTITT AAATSVTVPG AGVPSGSGGT VAPATMGSAR SHASSRASEN QSPSSSNYFS PRESTDFSSS SQEAFAASAV GSGERRGGGP VFPAPVVGSG GATSGKLLLE ADELCDDGGD GRGAVVPGAG LRRPTYTPPS IMPQKHWVYV KRGGNCPAPT PLVPQDPDLE EEEEEEDLVL TCEDDEDEEL GGSSRVPVGG GPEATLSISD VRTLSEPPDK GEEQVNFCES SNDFGPYEGG GPVAGLDDSG GPTPSSYAPS HPPRPLLPLD MQGNQILVFP SSSSSSSSQA PGQPPGNQAE HGAVTVGGTS VGSLGVPGSV GGVPGGTGSG DGNKIFLCHC GKAFSHKSMR DRHVNMHLNL RPFDCPVCNK KFKMKHHLTE HMKTHTGLKP YECGVCAKKF MWRDSFMRHR GHCERRHRLG GVGAVPGPGT PTGPSLPSKR ESPGVGGGSG DEASAATPPS SRRVWSPPRV HKVEMGFGGG GGAN
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