Prefoldin subunit 6 (PFDN6)

About Prefoldin subunit 6

Prefoldin subunit 6 (PFDN6) is a protein from Homo sapiens identified by UniProt accession O15212, 129 residues long. MolForge cross-references it against 0 known binders and 51 disease associations.

Target properties

Protein name	Prefoldin subunit 6
UniProt accession	O15212
Gene	PFDN6
Organism	Homo sapiens
Length	129 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (51)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.47
breast adenocarcinoma · score 0.23
hepatocellular carcinoma · score 0.13
hemoglobin D disease · score 0.05
hereditary persistence of fetal hemoglobin-sickle cell disease syndrome · score 0.05
hemoglobin E disease · score 0.04
dominant beta-thalassemia · score 0.04
Blackfan-Diamond anemia · score 0.04
delta-beta-thalassemia · score 0.04
MODY · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O15212-F1	alphafold	PREDICTED	94.40	—

Amino-acid sequence (129 residues)

MAELIQKKLQ GEVEKYQQLQ KDLSKSMSGR QKLEAQLTEN NIVKEELALL DGSNVVFKLL GPVLVKQELG EARATVGKRL DYITAEIKRY ESQLRDLERQ SEQQRETLAQ LQQEFQRAQA AKAGAPGKA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards