About Glutathione S-transferase A4
Glutathione S-transferase A4 (GSTA4) is a protein
from Homo sapiens identified by UniProt accession
O15217, 222 residues long.
MolForge cross-references it against 0 known binders and
100 disease associations.
Target properties
| Protein name | Glutathione S-transferase A4 |
|---|
| UniProt accession | O15217 |
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| Gene | GSTA4 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 222 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (100)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.48
- smoking behaviour measurement · score 0.25
- Parkinson disease · score 0.21
- Alzheimer disease · score 0.21
- multiple sclerosis · score 0.21
- lysosomal storage disease · score 0.21
- glioblastoma multiforme · score 0.16
- late-onset Alzheimers disease · score 0.14
- smoking status measurement · score 0.11
- attention deficit hyperactivity disorder · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O15217-F1 | alphafold | PREDICTED | 96.99 | — |
Amino-acid sequence (222 residues)
MAARPKLHYP NGRGRMESVR WVLAAAGVEF DEEFLETKEQ LYKLQDGNHL LFQQVPMVEI DGMKLVQTRS ILHYIADKHN LFGKNLKERT LIDMYVEGTL DLLELLIMHP FLKPDDQQKE VVNMAQKAII RYFPVFEKIL RGHGQSFLVG NQLSLADVIL LQTILALEEK IPNILSAFPF LQEYTVKLSN IPTIKRFLEP GSKKKPPPDE IYVRTVYNIF RP
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