Atypical chemokine receptor 5 (ACKR5)

About Atypical chemokine receptor 5

Atypical chemokine receptor 5 (ACKR5) is a protein from Homo sapiens identified by UniProt accession O15218, 404 residues long. MolForge cross-references it against 0 known binders and 111 disease associations.

Target properties

Protein name	Atypical chemokine receptor 5
UniProt accession	O15218
Gene	ACKR5
Organism	Homo sapiens
Length	404 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (111)

Diseases linked to this target (Open Targets).

neutrophil count · score 0.14
leukocyte count · score 0.12
heel bone mineral density · score 0.12
endometriosis · score 0.09
neoplasm · score 0.09
PHF-tau measurement · score 0.08
neurofibrillary tangles measurement · score 0.08
high density lipoprotein cholesterol measurement · score 0.08
melanoma · score 0.07
testosterone measurement · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O15218-F1	alphafold	PREDICTED	78.54	—

Amino-acid sequence (404 residues)

MSVKPSWGPG PSEGVTAVPT SDLGEIHNWT ELLDLFNHTL SECHVELSQS TKRVVLFALY LAMFVVGLVE NLLVICVNWR GSGRAGLMNL YILNMAIADL GIVLSLPVWM LEVTLDYTWL WGSFSCRFTH YFYFVNMYSS IFFLVCLSVD RYVTLTSASP SWQRYQHRVR RAMCAGIWVL SAIIPLPEVV HIQLVEGPEP MCLFMAPFET YSTWALAVAL STTILGFLLP FPLITVFNVL TACRLRQPGQ PKSRRHCLLL CAYVAVFVMC WLPYHVTLLL LTLHGTHISL HCHLVHLLYF FYDVIDCFSM LHCVINPILY NFLSPHFRGR LLNAVVHYLP KDQTKAGTCA SSSSCSTQHS IIITKGDSQP AAAAPHPEPS LSFQAHHLLP NTSPISPTQP LTPS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards