About NF-kappa-B-repressing factor
NF-kappa-B-repressing factor (NKRF) is a protein
from Homo sapiens identified by UniProt accession
O15226, 690 residues long.
MolForge cross-references it against 0 known binders and
84 disease associations.
Target properties
| Protein name | NF-kappa-B-repressing factor |
|---|
| UniProt accession | O15226 |
|---|
| Gene | NKRF |
|---|
| Organism | Homo sapiens |
|---|
| Length | 690 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (84)
Diseases linked to this target (Open Targets).
- myocardial infarction · score 0.06
- nail-patella syndrome · score 0.05
- acute myocardial infarction · score 0.05
- renal carcinoma · score 0.04
- triple-negative breast cancer · score 0.02
- neoplasm · score 0.02
- atherosclerosis · score 0.02
- colorectal cancer · score 0.01
- relapsing-remitting multiple sclerosis · score 0.01
- acute myeloid leukemia · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O15226-F1 | alphafold | PREDICTED | 69.58 | — |
Amino-acid sequence (690 residues)
MEKILQMAEG IDIGEMPSYD LVLSKPSKGQ KRHLSTCDGQ NPPKKQAGSK FHARPRFEPV HFVASSSKDE RQEDPYGPQT KEVNEQTHFA SMPRDIYQDY TQDSFSIQDG NSQYCDSSGF ILTKDQPVTA NMYFDSGNPA PSTTSQQANS QSTPEPSPSQ TFPESVVAEK QYFIEKLTAT IWKNLSNPEM TSGSDKINYT YMLTRCIQAC KTNPEYIYAP LKEIPPADIP KNKKLLTDGY ACEVRCQNIY LTTGYAGSKN GSRDRATELA VKLLQKRIEV RVVRRKFKHT FGEDLVVCQI GMSSYEFPPA LKPPEDLVVL GKDASGQPIF NASAKHWTNF VITENANDAI GILNNSASFN KMSIEYKYEM MPNRTWRCRV FLQDHCLAEG YGTKKTSKHA AADEALKILQ KTQPTYPSVK SSQCHTGSSP RGSGKKKDIK DLVVYENSSN PVCTLNDTAQ FNRMTVEYVY ERMTGLRWKC KVILESEVIA EAVGVKKTVK YEAAGEAVKT LKKTQPTVIN NLKKGAVEDV ISRNEIQGRS AEEAYKQQIK EDNIGNQLLR KMGWTGGGLG KSGEGIREPI SVKEQHKREG LGLDVERVNK IAKRDIEQII RNYARSESHT DLTFSRELTN DERKQIHQIA QKYGLKSKSH GVGHDRYLVV GRKRRKEDLL DQLKQEGQVG HYELVMPQAN
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