About Dihydroxyacetone phosphate acyltransferase
Dihydroxyacetone phosphate acyltransferase (GNPAT) is a protein
from Homo sapiens identified by UniProt accession
O15228, 680 residues long.
MolForge cross-references it against 0 known binders and
116 disease associations.
Target properties
| Protein name | Dihydroxyacetone phosphate acyltransferase |
|---|
| UniProt accession | O15228 |
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| Gene | GNPAT |
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| Organism | Homo sapiens |
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| Length | 680 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (116)
Diseases linked to this target (Open Targets).
- rhizomelic chondrodysplasia punctata type 2 · score 0.83
- rhizomelic chondrodysplasia punctata · score 0.57
- neurodegenerative disease · score 0.41
- glyceronephosphate O-acyltransferase deficiency · score 0.37
- Parkinson disease · score 0.36
- Alzheimer disease · score 0.36
- multiple sclerosis · score 0.36
- lysosomal storage disease · score 0.36
- genetic disorder · score 0.19
- low grade glioma · score 0.18
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O15228-F1 | alphafold | PREDICTED | 88.51 | — |
Amino-acid sequence (680 residues)
MESSSSSNSY FSVGPTSPSA VVLLYSKELK KWDEFEDILE ERRHVSDLKF AMKCYTPLVY KGITPCKPID IKCSVLNSEE IHYVIKQLSK ESLQSVDVLR EEVSEILDEM SHKLRLGAIR FCAFTLSKVF KQIFSKVCVN EEGIQKLQRA IQEHPVVLLP SHRSYIDFLM LSFLLYNYDL PVPVIAAGMD FLGMKMVGEL LRMSGAFFMR RTFGGNKLYW AVFSEYVKTM LRNGYAPVEF FLEGTRSRSA KTLTPKFGLL NIVMEPFFKR EVFDTYLVPI SISYDKILEE TLYVYELLGV PKPKESTTGL LKARKILSEN FGSIHVYFGD PVSLRSLAAG RMSRSSYNLV PRYIPQKQSE DMHAFVTEVA YKMELLQIEN MVLSPWTLIV AVLLQNRPSM DFDALVEKTL WLKGLTQAFG GFLIWPDNKP AEEVVPASIL LHSNIASLVK DQVILKVDSG DSEVVDGLML QHITLLMCSA YRNQLLNIFV RPSLVAVALQ MTPGFRKEDV YSCFRFLRDV FADEFIFLPG NTLKDFEEGC YLLCKSEAIQ VTTKDILVTE KGNTVLEFLV GLFKPFVESY QIICKYLLSE EEDHFSEEQY LAAVRKFTSQ LLDQGTSQCY DVLSSDVQKN ALAACVRLGV VEKKKINNNC IFNVNEPATT KLEEMLGCKT PIGKPATAKL
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