About Zinc finger protein 185
Zinc finger protein 185 (ZNF185) is a protein
from Homo sapiens identified by UniProt accession
O15231, 689 residues long.
MolForge cross-references it against 0 known binders and
37 disease associations.
Target properties
| Protein name | Zinc finger protein 185 |
|---|
| UniProt accession | O15231 |
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| Gene | ZNF185 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 689 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (37)
Diseases linked to this target (Open Targets).
- neoplasm · score 0.07
- cancer · score 0.06
- squamous cell carcinoma · score 0.03
- head and neck squamous cell carcinoma · score 0.03
- esophageal squamous cell carcinoma · score 0.02
- hepatocellular carcinoma · score 0.02
- oral squamous cell carcinoma · score 0.02
- skin squamous cell carcinoma · score 0.01
- prostate carcinoma · score 0.01
- Adams-Oliver syndrome · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O15231-F1 | alphafold | PREDICTED | 50.19 | — |
Amino-acid sequence (689 residues)
MSISALGGRT KGKPLPPGEE ERNNVLKQMK VRTTLKGDKS WITKQDESEG RTIELPSGRS RATSFSSAGE VPKPRPPSTR APTGYIIRGV FTKPIDSSSQ PQQQFPKANG TPKSAASLVR TANAGPPRPS SSGYKMTTED YKKLAPYNIR RSSTSGDTEE EEEEEVVPFS SDEQKRRSEA ASGVLRRTAP REHSYVLSAA KKSTGPTQET QAPFIAKRVE VVEEDGPSEK SQDPPALARS TPGSNSADGG RTKASRAIWI ECLPSMPSPA GSQELSSRGE EIVRLQILTP RAGLRLVAPD VEGMRSSPGN KDKEAPCSRE LQRDLAGEEA FRAPNTDAAR SSAQLSDGNV GSGATGSRPE GLAAVDIGSE RGSSSATSVS AVPADRKSNS TAAQEDAKAD PKGALADYEG KDVATRVGEA WQERPGAPRG GQGDPAVPAQ QPADPSTPER QSSPSGSEQL VRRESCGSSV LTDFEGKDVA TKVGEAWQDR PGAPRGGQGD PAVPTQQPAD PSTPEQQNSP SGSEQFVRRE SCTSRVRSPS SCMVTVTVTA TSEQPHIYIP APASELDSSS TTKGILFVKE YVNASEVSSG KPVSARYSNV SSIEDSFAME KKPPCGSTPY SERTTGGICT YCNREIRDCP KITLEHLGIC CHEYCFKCGI CSKPMGDLLD QIFIHRDTIH CGKCYEKLF
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