About Small ribosomal subunit protein uS12m
Small ribosomal subunit protein uS12m (MRPS12) is a protein
from Homo sapiens identified by UniProt accession
O15235, 138 residues long.
MolForge cross-references it against 0 known binders and
64 disease associations.
Target properties
| Protein name | Small ribosomal subunit protein uS12m |
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| UniProt accession | O15235 |
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| Gene | MRPS12 |
|---|
| Organism | Homo sapiens |
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| Length | 138 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (64)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.52
- hyperuricemia-pulmonary hypertension-renal failure-alkalosis syndrome · score 0.12
- hypertrophic cardiomyopathy · score 0.06
- dilated cardiomyopathy · score 0.05
- left ventricular noncompaction · score 0.05
- dilated cardiomyopathy 1M · score 0.04
- dilated cardiomyopathy 2A · score 0.04
- dilated cardiomyopathy 1W · score 0.04
- dilated cardiomyopathy 1CC · score 0.04
- Sensorineural deafness with dilated cardiomyopathy · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O15235-F1 | alphafold | PREDICTED | 86.45 | — |
Amino-acid sequence (138 residues)
MSWSGLLHGL NTSLTCGPAL VPRLWATCSM ATLNQMHRLG PPKRPPRKLG PTEGRPQLKG VVLCTFTRKP KKPNSANRKC CRVRLSTGRE AVCFIPGEGH TLQEHQIVLV EGGRTQDLPG VKLTVVRGKY DCGHVQKK
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