NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 (NDUFA1)

About NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 (NDUFA1) is a protein from Homo sapiens identified by UniProt accession O15239, 70 residues long. MolForge cross-references it against 0 known binders and 250 disease associations.

Target properties

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Disease associations (250)

Diseases linked to this target (Open Targets).

• mitochondrial complex I deficiency · score 0.72
• type 2 diabetes mellitus · score 0.61
• diabetes mellitus · score 0.60
• polycystic ovary syndrome · score 0.60
• type 1 diabetes mellitus · score 0.58
• gestational diabetes · score 0.58
• obesity · score 0.57
• prediabetes syndrome · score 0.56
• schizophrenia · score 0.55
• insulin resistance · score 0.55

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Amino-acid sequence (70 residues)

External references