About Neurosecretory protein VGF
Neurosecretory protein VGF (VGF) is a protein
from Homo sapiens identified by UniProt accession
O15240, 615 residues long.
MolForge cross-references it against 0 known binders and
252 disease associations.
Target properties
| Protein name | Neurosecretory protein VGF |
|---|
| UniProt accession | O15240 |
|---|
| Gene | VGF |
|---|
| Organism | Homo sapiens |
|---|
| Length | 615 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (252)
Diseases linked to this target (Open Targets).
- vitamin D measurement · score 0.16
- axial length measurement · score 0.10
- infect · score 0.08
- infection · score 0.08
- lung adenocarcinoma · score 0.07
- Lewy body dementia · score 0.07
- oral squamous cell carcinoma · score 0.07
- serum metabolite measurement · score 0.07
- Paraganglioma · score 0.07
- glucocorticoid-remediable aldosteronism · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O15240-F1 | alphafold | PREDICTED | 60.43 | — |
Amino-acid sequence (615 residues)
MKALRLSASA LFCLLLINGL GAAPPGRPEA QPPPLSSEHK EPVAGDAVPG PKDGSAPEVR GARNSEPQDE GELFQGVDPR ALAAVLLQAL DRPASPPAPS GSQQGPEEEA AEALLTETVR SQTHSLPAPE SPEPAAPPRP QTPENGPEAS DPSEELEALA SLLQELRDFS PSSAKRQQET AAAETETRTH TLTRVNLESP GPERVWRASW GEFQARVPER APLPPPAPSQ FQARMPDSGP LPETHKFGEG VSSPKTHLGE ALAPLSKAYQ GVAAPFPKAR RPESALLGGS EAGERLLQQG LAQVEAGRRQ AEATRQAAAQ EERLADLASD LLLQYLLQGG ARQRGLGGRG LQEAAEERES AREEEEAEQE RRGGEERVGE EDEEAAEAEA EAEEAERARQ NALLFAEEED GEAGAEDKRS QEETPGHRRK EAEGTEEGGE EEDDEEMDPQ TIDSLIELST KLHLPADDVV SIIEEVEEKR KRKKNAPPEP VPPPRAAPAP THVRSPQPPP PAPAPARDEL PDWNEVLPPW DREEDEVYPP GPYHPFPNYI RPRTLQPPSA LRRRHYHHAL PPSRHYPGRE AQARRAQEEA EAEERRLQEQ EELENYIEHV LLRRP
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