About Leptin receptor gene-related protein
Leptin receptor gene-related protein (LEPROT) is a protein
from Homo sapiens identified by UniProt accession
O15243, 131 residues long.
MolForge cross-references it against 0 known binders and
80 disease associations.
Target properties
| Protein name | Leptin receptor gene-related protein |
|---|
| UniProt accession | O15243 |
|---|
| Gene | LEPROT |
|---|
| Organism | Homo sapiens |
|---|
| Length | 131 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (80)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.45
- non-alcoholic steatohepatitis · score 0.23
- longitudinal BMI measurement · score 0.23
- neutrophil count · score 0.22
- leukocyte count · score 0.22
- lymphocyte percentage of leukocytes · score 0.22
- myeloid white cell count · score 0.20
- sum of neutrophil and eosinophil counts · score 0.18
- sum of basophil and neutrophil counts · score 0.18
- granulocyte count · score 0.18
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O15243-F1 | alphafold | PREDICTED | 81.78 | — |
Amino-acid sequence (131 residues)
MAGVKALVAL SFSGAIGLTF LMLGCALEDY GVYWPLFVLI FHAISPIPHF IAKRVTYDSD ATSSACRELA YFFTTGIVVS AFGFPVILAR VAVIKWGACG LVLAGNAVIF LTIQGFFLIF GRGDDFSWEQ W
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