Chloride intracellular channel protein 2 (CLIC2)

About Chloride intracellular channel protein 2

Chloride intracellular channel protein 2 (CLIC2) is a protein from Homo sapiens identified by UniProt accession O15247, 247 residues long. MolForge cross-references it against 0 known binders and 68 disease associations.

Target properties

Protein name	Chloride intracellular channel protein 2
UniProt accession	O15247
Gene	CLIC2
Organism	Homo sapiens
Length	247 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (68)

Diseases linked to this target (Open Targets).

X-linked intellectual disability-cardiomegaly-congestive heart failure syndrome · score 0.48
neurodegenerative disease · score 0.47
X-linked intellectual disability - cardiomegaly - congestive heart failure · score 0.37
breast adenocarcinoma · score 0.25
endometrial cancer · score 0.11
cancer · score 0.09
breast cancer · score 0.07
neoplasm · score 0.06
systemic lupus erythematosus · score 0.05
Systemic lupus erythematosus · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O15247-F1	alphafold	PREDICTED	92.96	—

Amino-acid sequence (247 residues)

MSGLRPGTQV DPEIELFVKA GSDGESIGNC PFCQRLFMIL WLKGVKFNVT TVDMTRKPEE LKDLAPGTNP PFLVYNKELK TDFIKIEEFL EQTLAPPRYP HLSPKYKESF DVGCNLFAKF SAYIKNTQKE ANKNFEKSLL KEFKRLDDYL NTPLLDEIDP DSAEEPPVSR RLFLDGDQLT LADCSLLPKL NIIKVAAKKY RDFDIPAEFS GVWRYLHNAY AREEFTHTCP EDKEIENTYA NVAKQKS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards